Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis

Yumiko Imai, Keiji Kuba, Takayo Ohto-Nakanishi, Josef M. Penninger

Research output: Contribution to journalReview articlepeer-review

170 Citations (Scopus)

Abstract

Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin-angiotensin system by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. For instance, in the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in SARS pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.

Original languageEnglish
Pages (from-to)405-410
Number of pages6
JournalCirculation Journal
Volume74
Issue number3
DOIs
Publication statusPublished - Mar 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis'. Together they form a unique fingerprint.

Cite this