Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: The Hisayama study

Yasufumi Doi, Toshiharu Ninomiya, Yoichiro Hirakawa, Otowa Takahashi, Naoko Mukai, Jun Hata, Masanori Iwase, Takanari Kitazono, Yuichi Oike, Yutaka Kiyohara

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


OBJECTIVE - To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS - A total of 2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes were followed up for 7 years. Serum ANGPTL2 levels were divided into quartile categories at baseline: >2.15, 2.16-2.71, 2.72-3.40, and ≥3.41 ng/mL. During follow-up, 221 participants developed T2DM. RESULTS - In multivariate analyses, after adjusting for comprehensive risk factors and high-sensitivity C-reactive protein (hs-CRP) levels, the risk of developing T2DM was significantly higher in the highest ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14-2.85; P = 0.01). CONCLUSIONS - Elevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general population, independent of other risk factors including hs-CRP levels.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalDiabetes care
Issue number1
Publication statusPublished - Jan 2013

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing


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