Angiogenesis as a new target for cancer treatment

Mayumi Ono, Hiroto Izumi, Shigeo Yoshida, Daisuke Goto, Sei Ichiro Jimi, Naoyuki Kawahara, Tadahisa Shono, Shin Ushiro, Masahiro Ryuto, Kimitoshi Kohno, Yasafumi Sato, Michihiko Kuwano

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Neovascularization is often required for rapid growth of solid tumors and also limits vascular metastasis of tumor cells. Neovascularization-targeting agents are a recent innovation that may be a novel means of anticancer therapy. These antiangiogenic drugs have been developed by targeting cell proliferation of vascular endothelial cells, basement-membrane-degrading enzymes, angiogenic factors/receptors, extracellular matrix, angiogenesis signaling, and cell-cell/cell-matrix interactions. In this report, we describe how tumor angiogenesis occurs and how antiangiogenic agents are developed.

Original languageEnglish
Pages (from-to)S78-S82
JournalCancer Chemotherapy and Pharmacology, Supplement
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Cancer Research


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