Anesthesia for a patient with xeroderma pigmentosum

Ryohei Miyazaki, Taro Nagata, Tetsuya Kai, Shosuke Takahashi

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10 Citations (Scopus)


A 23-year-old man with xeroderma pigmentosum underwent laparoscopic cholecystectomy. He experienced transient worsening of the neurological symptom after anesthesia with volatile agents in the previous surgery. Because volatile anesthetics potentially cause genotoxic effects in patients with xeroderma pigmentosum, this time we chose total intravenous anesthesia (TIVA). The intraoperative management and the postoperative course were uneventful this time. From these two anesthesia experiences in one patient, we suggest that TIVA is more appropriate than anesthesia with volatile agents as a method for general anesthesia for xeroderma pigmentosum patients. Minimum usage of muscle relaxants under the monitoring of neuromuscular blockade is also recommended, since xeroderma pigmentosum patients are sensitive to muscle relaxants due to the neuronal dysfunction and muscle atrophy.

Original languageEnglish
Pages (from-to)439-441
Number of pages3
JournalJapanese Journal of Anesthesiology
Issue number4
Publication statusPublished - Apr 2007

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine


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