Androgen - Producing adrenocortical adenoma with acromegaly due to growth hormone - Producing pituitary tumor: A case report

We here in report a case of androgen - producing adrenocortical adenoma with a pituitary tumor in a woman in her 30's. Volume increase of limbs appeared in 2004. Eight years later, changes in facial appearance, hirsutism of the trunk and limbs and hair loss in the crown region appeared, and visual defects appeared nine years later. In 2014, she was diagnosed with acromegaly by blood and imaging tests. At the same time, she had signs of masculinization and high levels of serum testosterone and DHEA-S, and an image examination revealed a left adrenal tumor. Under the diagnosis of an androgen - producing adrenal tumor, laparoscopic adrenalectomy was performed. The diagnosis was cortical adenoma. After surgery, the levels of serum testosterone and DHEA-S rapidly reduced to normal levels. We treated the acromegaly by surgery, medication and stereotactic radiotherapy, however, the clinical symptoms and laboratory data did not improve.