TY - JOUR
T1 - Analysis of tumor necrosis factor-α gene promoter polymorphisms in anorexia nervosa
AU - Ando, Tetsuya
AU - Ishikawa, Toshio
AU - Kawamura, Noriyuki
AU - Karibe, Masami
AU - Oba, Mariko
AU - Tatsuta, Naoko
AU - Hara, Shinichiro
AU - Takii, Masato
AU - Naruo, Tetsuo
AU - Takei, Michiko
AU - Kurokawa, Nobuo
AU - Nozoe, Shinichi
AU - Kubo, Chiharu
AU - Komaki, Gen
PY - 2001/10/30
Y1 - 2001/10/30
N2 - Elevated plasma tumor necrosis factor-α (TNFα) levels and enhanced spontaneous TNFα release from peripheral blood mononuclear cells in patients with anorexia nervosa (AN) have been reported. TNFα activates the hypothalamic-pituitary-adrenal axis and reduces food intake, which is characteristic of eating disorders. Recently, three novel polymorphisms in the 5′-flanking region of the TNFα gene were reported at positions -1031(T → C substitution), -863 (C → A) and -857 (C → T). Differences in these alleles are reportedly related to altered TNFα-transcriptional promoter activity. Therefore, we performed a case-control association analysis to determine whether any of those three polymorphisms in the TNFα promoter region were involved in a predisposition to AN. The results of our analysis of a cohort of 79 female Japanese AN sufferers and 127 normal female control subjects provide no support for the hypothesis that -1031T/C, -863 C /A and -857C/T polymorphisms in the TNFα gene promoter region influence the susceptibility to AN.
AB - Elevated plasma tumor necrosis factor-α (TNFα) levels and enhanced spontaneous TNFα release from peripheral blood mononuclear cells in patients with anorexia nervosa (AN) have been reported. TNFα activates the hypothalamic-pituitary-adrenal axis and reduces food intake, which is characteristic of eating disorders. Recently, three novel polymorphisms in the 5′-flanking region of the TNFα gene were reported at positions -1031(T → C substitution), -863 (C → A) and -857 (C → T). Differences in these alleles are reportedly related to altered TNFα-transcriptional promoter activity. Therefore, we performed a case-control association analysis to determine whether any of those three polymorphisms in the TNFα promoter region were involved in a predisposition to AN. The results of our analysis of a cohort of 79 female Japanese AN sufferers and 127 normal female control subjects provide no support for the hypothesis that -1031T/C, -863 C /A and -857C/T polymorphisms in the TNFα gene promoter region influence the susceptibility to AN.
UR - http://www.scopus.com/inward/record.url?scp=0034781082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034781082&partnerID=8YFLogxK
U2 - 10.1097/00041444-200109000-00009
DO - 10.1097/00041444-200109000-00009
M3 - Article
C2 - 11702059
AN - SCOPUS:0034781082
SN - 0955-8829
VL - 11
SP - 161
EP - 164
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 3
ER -
