Elevated plasma tumor necrosis factor-α (TNFα) levels and enhanced spontaneous TNFα release from peripheral blood mononuclear cells in patients with anorexia nervosa (AN) have been reported. TNFα activates the hypothalamic-pituitary-adrenal axis and reduces food intake, which is characteristic of eating disorders. Recently, three novel polymorphisms in the 5′-flanking region of the TNFα gene were reported at positions -1031(T → C substitution), -863 (C → A) and -857 (C → T). Differences in these alleles are reportedly related to altered TNFα-transcriptional promoter activity. Therefore, we performed a case-control association analysis to determine whether any of those three polymorphisms in the TNFα promoter region were involved in a predisposition to AN. The results of our analysis of a cohort of 79 female Japanese AN sufferers and 127 normal female control subjects provide no support for the hypothesis that -1031T/C, -863 C /A and -857C/T polymorphisms in the TNFα gene promoter region influence the susceptibility to AN.
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry