Analysis of cellular signal transduction from an information theoretic approach

Shinsuke Uda, Shinya Kuroda

    Research output: Contribution to journalReview articlepeer-review

    27 Citations (Scopus)

    Abstract

    Signal transduction processes the information of various cellular functions, including cell proliferation, differentiation, and death. The information for controlling cell fate is transmitted by concentrations of cellular signaling molecules. However, how much information is transmitted in signaling pathways has thus far not been investigated. Shannon's information theory paves the way to quantitatively analyze information transmission in signaling pathways. The theory has recently been applied to signal transduction, and mutual information of signal transduction has been determined to be a measure of information transmission. We review this work and provide an overview of how signal transduction transmits informational input and exerts biological output.

    Original languageEnglish
    Pages (from-to)24-31
    Number of pages8
    JournalSeminars in Cell and Developmental Biology
    Volume51
    DOIs
    Publication statusPublished - Mar 1 2016

    All Science Journal Classification (ASJC) codes

    • Developmental Biology
    • Cell Biology

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