Analysis of Capillary Electrophoresis Noise Characteristics

Gong Chen, Xi Fang Zhu, Xiao Ming Dou, Chen Chen Liu, Qing Quan Xu, Yoshinori Yamaguchi, Yi Ni

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


In order to optimize the fluorescence detection capillary electrophoresis system and improve the detection sensitivity, the signal noise characters were studied when separating 100~1000 base pair deoxyribonucleic acid ladder under direct current electric field in hydroxyethyl cellulose solutions. The dependence of signal noise on separation electric field intensity, polymer concentration, hydroxyethyl cellulose molecular weight, the effective length and the capillary shape were investigated. Experiment result shows that optimum parameters can be obtained under best signal noise ratio, which are the separation electric field strength of 500~600 V/cm, hydroxyethyl cellulose concentration of 0.6%~0.7%, hydroxyethyl cellulose molecular weight of 250, round inner diameter of 50 μm and effective capillary length of 8 cm.

Original languageEnglish
Article number0612004
JournalGuangzi Xuebao/Acta Photonica Sinica
Issue number6
Publication statusPublished - Jun 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics


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