An unusual autopsy case of pyogenic liver abscess caused by periodontal bacteria

Hideki Ohyama, Keiji Nakasho, Koji Yamanegi, Yuichiro Noiri, Ayako Kuhara, Nahoko Kato-Kogoe, Naoko Yamada, Masaki Hata, Fusanori Nishimura, Shigeyuki Ebisu, Nobuyuki Terada

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35 Citations (Scopus)


Pyogenic liver abscess (PLA) formation is thought to originate from the transmission of infection via three major routes including the biliary tract, portal vein and hepatic artery. However, about 50% of PLA cases are considered to be cryptogenic. Here we report an unusual autopsy case of PLA associated with periodontopathic bacterial infection. A 59-year-old female suddenly developed cardiopulmonary arrest and died. Despite macroscopic and microscopic examinations, the infectious routes and source of infection were unidentified, and the case appeared to be cryptogenic. Since this patient had suffered severe periodontitis for a long period of time, we investigated the involvement of periodontal infection in PLA formation by performing immunohistochemical analyses. We identified several periodontopathic bacterial species in the PLA of this patient, including Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia and Porphyromonas gingivalis. Thus, we demonstrate here that periodontal infection is a potential source of infection in the formation of PLA.

Original languageEnglish
Pages (from-to)381-383
Number of pages3
JournalJapanese Journal of Infectious Diseases
Issue number5
Publication statusPublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


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