An intravitreal cannula system: long-term follow-up study

Tatsuro Ishibashi, Koichiro Miki, Randi Patterson, Stephen J. Ryan

Research output: Contribution to journalArticlepeer-review


An intravitreal cannula for chronic drug delivery was implanted in the eyes of two rabbits and one monkey. The rabbits were followed up for three years after surgery and the monkey was followed up for two and one-half years. Clinical observations did not reveal any adverse effects from the cannula implantation. Patency of the cannula was demonstrated by using sodium fluorescein. Histopathological studies with light and electron microscopy revealed the scar tissue around the cannula to be minimal and localized to the wound site. The optic nerve and the retina and choroid at the posterior pole did not show any abnormalities. These results suggest that this system can be used for repeated or continuous drug delivery to the vitreous over a long period of time in experimental models.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalInternational Ophthalmology
Issue number1
Publication statusPublished - Apr 1986

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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