TY - JOUR
T1 - An improved method for estimating core size distributions of magnetic nanoparticles via magnetization harmonics
AU - Sun, Yi
AU - Ye, Na
AU - Wang, Dandan
AU - Du, Zhongzhou
AU - Bai, Shi
AU - Yoshida, Takashi
N1 - Funding Information:
Funding: This work was supported in part by the National Natural Science Foundation of China under Grant 61803346, in part by the Science and Technology Program of Henan under Grant 192102310213, in part by Special Funds for the province of Henan Province under Grant 17KYYWF0207 and Grant 17KYYWF0303, and by the Japan Society for the Promotion of Science under Grant-in-Aid for Scientific Research (C) JP18K04170 and Grant-in-Aid for JSPS Fellows JP18F18760. We thank Alan Burns, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/9
Y1 - 2020/9
N2 - The core size distribution is an important physical characteristic of magnetic nanoparticles (MNPs) because it seriously affects biomedical and biological applications. In this study, we proposed an improved method for estimating the distributions, which optimizes the excitation frequency based on AC susceptibility to avoid the effects of Brownian relaxation. Moreover, the first, third, and fifth magnetization harmonics under different excitation field strengths are used for estimating core size distributions to avoid measuring higher harmonics. The experiment results show that the improved AC harmonic method can accurately and quickly estimate the distribution of large core sizes compared with the method of static magnetization (M–H) curves, which is a competitive advantage in MNP immunoassays.
AB - The core size distribution is an important physical characteristic of magnetic nanoparticles (MNPs) because it seriously affects biomedical and biological applications. In this study, we proposed an improved method for estimating the distributions, which optimizes the excitation frequency based on AC susceptibility to avoid the effects of Brownian relaxation. Moreover, the first, third, and fifth magnetization harmonics under different excitation field strengths are used for estimating core size distributions to avoid measuring higher harmonics. The experiment results show that the improved AC harmonic method can accurately and quickly estimate the distribution of large core sizes compared with the method of static magnetization (M–H) curves, which is a competitive advantage in MNP immunoassays.
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U2 - 10.3390/nano10091623
DO - 10.3390/nano10091623
M3 - Article
AN - SCOPUS:85089658516
SN - 2079-4991
VL - 10
SP - 1
EP - 12
JO - Nanomaterials
JF - Nanomaterials
IS - 9
M1 - 1623
ER -