TY - JOUR
T1 - An enteric-coated dry emulsion formulation for oral insulin delivery
AU - Toorisaka, Eiichi
AU - Hashida, Masakazu
AU - Kamiya, Noriho
AU - Ono, Hiroshige
AU - Kokazu, Yuko
AU - Goto, Masahiro
N1 - Funding Information:
The present work is supported by a Grant-in-Aid for the 21st Century COE Program, “Functional Innovation of Molecular Informatics” from the Ministry of Education, Culture, Science, Sports and Technology of Japan (to M.G.) and by Kyushu University Foundation (to N.K.).
PY - 2005/9/20
Y1 - 2005/9/20
N2 - A novel oral dosage formulation of insulin consisting of a surfactant, a vegetable oil, and a pH-responsive polymer has been developed. First, a solid-in-oil (S/O) suspension containing a surfactant-insulin complex was prepared. Solid-in-oil-in-water (S/O/W) emulsions were obtained by homogenizing the S/O suspension and the aqueous solution of hydroxypropylmethylcellulose phthalate (HPMCP). A microparticulate solid emulsion formulation was successfully prepared from the S/O/W emulsions by extruding them to an acidic aqueous solution, followed by lyophilization. The insulin release from the resultant dry emulsion responded to the change in external environment simulated by gastrointestinal conditions, suggesting that the new enteric-coated dry emulsion formulation is potentially applicable for the oral delivery of peptide and protein drugs.
AB - A novel oral dosage formulation of insulin consisting of a surfactant, a vegetable oil, and a pH-responsive polymer has been developed. First, a solid-in-oil (S/O) suspension containing a surfactant-insulin complex was prepared. Solid-in-oil-in-water (S/O/W) emulsions were obtained by homogenizing the S/O suspension and the aqueous solution of hydroxypropylmethylcellulose phthalate (HPMCP). A microparticulate solid emulsion formulation was successfully prepared from the S/O/W emulsions by extruding them to an acidic aqueous solution, followed by lyophilization. The insulin release from the resultant dry emulsion responded to the change in external environment simulated by gastrointestinal conditions, suggesting that the new enteric-coated dry emulsion formulation is potentially applicable for the oral delivery of peptide and protein drugs.
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U2 - 10.1016/j.jconrel.2005.05.022
DO - 10.1016/j.jconrel.2005.05.022
M3 - Article
C2 - 16039746
AN - SCOPUS:24344446947
SN - 0168-3659
VL - 107
SP - 91
EP - 96
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -