An Autopsy Case of COVID-19 with New Diffuse Pulmonary Ossification

Taisuke Nakagawa; Yasuaki Kotetsu; Katsumi Takizawa; Michihiro Yoshimi; Isamu Okamoto; Shohei Takata

doi:10.2169/internalmedicine.3096-23

An Autopsy Case of COVID-19 with New Diffuse Pulmonary Ossification

Taisuke Nakagawa, Yasuaki Kotetsu, Katsumi Takizawa, Michihiro Yoshimi, Isamu Okamoto, Shohei Takata

Research output: Contribution to journal › Article › peer-review

Abstract

We present the case of a 61-year-old man who developed coronavirus disease 2019 (COVID-19) and died during treatment for relapsing polychondritis. The patient was intubated and treated with steroid pulse therapy, remdecivir, antibacterial agents, baricitinib, and tocilizumab. However, his respiratory condition worsened, and he died 108 days after disease onset. An autopsy revealed diffuse alveolar damage in the fibrotic phase in all lung lobes, diffuse pulmonary ossification, and cytomegalovirus-infected cells in the middle lobe of the right lung. We herein discuss the clinical features and pathological findings of COVID-19 in immunosuppressed patients.

Original language	English
Pages (from-to)	1459-1463
Number of pages	5
Journal	Internal Medicine
Volume	63
Issue number	10
DOIs	https://doi.org/10.2169/internalmedicine.3096-23
Publication status	Published - 2024

All Science Journal Classification (ASJC) codes

Internal Medicine

Access to Document

10.2169/internalmedicine.3096-23

Cite this

@article{18219defa28c47708669d9563d2a9b52,

title = "An Autopsy Case of COVID-19 with New Diffuse Pulmonary Ossification",

abstract = "We present the case of a 61-year-old man who developed coronavirus disease 2019 (COVID-19) and died during treatment for relapsing polychondritis. The patient was intubated and treated with steroid pulse therapy, remdecivir, antibacterial agents, baricitinib, and tocilizumab. However, his respiratory condition worsened, and he died 108 days after disease onset. An autopsy revealed diffuse alveolar damage in the fibrotic phase in all lung lobes, diffuse pulmonary ossification, and cytomegalovirus-infected cells in the middle lobe of the right lung. We herein discuss the clinical features and pathological findings of COVID-19 in immunosuppressed patients.",

keywords = "COVID-19, diffuse alveolar damage, diffuse pulmonary ossification",

author = "Taisuke Nakagawa and Yasuaki Kotetsu and Katsumi Takizawa and Michihiro Yoshimi and Isamu Okamoto and Shohei Takata",

year = "2024",

doi = "10.2169/internalmedicine.3096-23",

language = "English",

volume = "63",

pages = "1459--1463",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "10",

}

TY - JOUR

T1 - An Autopsy Case of COVID-19 with New Diffuse Pulmonary Ossification

AU - Nakagawa, Taisuke

AU - Kotetsu, Yasuaki

AU - Takizawa, Katsumi

AU - Yoshimi, Michihiro

AU - Okamoto, Isamu

AU - Takata, Shohei

PY - 2024

Y1 - 2024

N2 - We present the case of a 61-year-old man who developed coronavirus disease 2019 (COVID-19) and died during treatment for relapsing polychondritis. The patient was intubated and treated with steroid pulse therapy, remdecivir, antibacterial agents, baricitinib, and tocilizumab. However, his respiratory condition worsened, and he died 108 days after disease onset. An autopsy revealed diffuse alveolar damage in the fibrotic phase in all lung lobes, diffuse pulmonary ossification, and cytomegalovirus-infected cells in the middle lobe of the right lung. We herein discuss the clinical features and pathological findings of COVID-19 in immunosuppressed patients.

AB - We present the case of a 61-year-old man who developed coronavirus disease 2019 (COVID-19) and died during treatment for relapsing polychondritis. The patient was intubated and treated with steroid pulse therapy, remdecivir, antibacterial agents, baricitinib, and tocilizumab. However, his respiratory condition worsened, and he died 108 days after disease onset. An autopsy revealed diffuse alveolar damage in the fibrotic phase in all lung lobes, diffuse pulmonary ossification, and cytomegalovirus-infected cells in the middle lobe of the right lung. We herein discuss the clinical features and pathological findings of COVID-19 in immunosuppressed patients.

KW - COVID-19

KW - diffuse alveolar damage

KW - diffuse pulmonary ossification

UR - http://www.scopus.com/inward/record.url?scp=85193456633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85193456633&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.3096-23

DO - 10.2169/internalmedicine.3096-23

M3 - Article

C2 - 38432960

AN - SCOPUS:85193456633

SN - 0918-2918

VL - 63

SP - 1459

EP - 1463

JO - Internal Medicine

JF - Internal Medicine

IS - 10

ER -

An Autopsy Case of COVID-19 with New Diffuse Pulmonary Ossification

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this