An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups

Shigeki Sasaki; Yasutaka Takase; Kenji Koga

doi:10.1016/S0040-4039(00)98026-2

An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups

Shigeki Sasaki, Yasutaka Takase, Kenji Koga

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.

Original language	English
Pages (from-to)	6051-6054
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(00)98026-2
Publication status	Published - 1990

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)98026-2

Cite this

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title = "An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups",

abstract = "An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.",

author = "Shigeki Sasaki and Yasutaka Takase and Kenji Koga",

year = "1990",

doi = "10.1016/S0040-4039(00)98026-2",

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AU - Sasaki, Shigeki

AU - Takase, Yasutaka

AU - Koga, Kenji

PY - 1990

Y1 - 1990

N2 - An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.

AB - An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.

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U2 - 10.1016/S0040-4039(00)98026-2

DO - 10.1016/S0040-4039(00)98026-2

M3 - Article

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SN - 0040-4039

VL - 31

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups

Abstract

All Science Journal Classification (ASJC) codes

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