An adolescent female having hepatocellular carcinoma associated with hepatitis B virus genotype H with a deletion mutation in the pre-S2 region

Utako Oba; Yuhki Koga; Takayuki Hoshina; Aiko Suminoe; Kenji Abe; Makoto Hayashida; Tomoaki Taguchi; Toshiro Hara

doi:10.1016/j.jiac.2014.10.015

An adolescent female having hepatocellular carcinoma associated with hepatitis B virus genotype H with a deletion mutation in the pre-S2 region

Utako Oba, Yuhki Koga, Takayuki Hoshina, Aiko Suminoe, Kenji Abe, Makoto Hayashida, Tomoaki Taguchi, Toshiro Hara

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The genotypes of hepatitis B virus (HBV) have a distinct geographical distribution, with HBV genotype H being very rare in East Asia, including Japan. We herein report the case of a 12-year-old Japanese female with hepatocellular carcinoma (HCC) who exhibited HBV genotype H. Notably, the HBV isolated from the patient had a deletion mutation in the pre-S2 region. The genome of HBV genotype H in the patient with HCC has not been analyzed in detail. The deletion mutations in the pre-S2 region, which may play an important role in hepatocarcinogenesis in children, can also present in genotype H.

Original language	English
Pages (from-to)	302-304
Number of pages	3
Journal	Journal of Infection and Chemotherapy
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.jiac.2014.10.015
Publication status	Published - Apr 1 2015

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2014.10.015

Cite this

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title = "An adolescent female having hepatocellular carcinoma associated with hepatitis B virus genotype H with a deletion mutation in the pre-S2 region",

abstract = "The genotypes of hepatitis B virus (HBV) have a distinct geographical distribution, with HBV genotype H being very rare in East Asia, including Japan. We herein report the case of a 12-year-old Japanese female with hepatocellular carcinoma (HCC) who exhibited HBV genotype H. Notably, the HBV isolated from the patient had a deletion mutation in the pre-S2 region. The genome of HBV genotype H in the patient with HCC has not been analyzed in detail. The deletion mutations in the pre-S2 region, which may play an important role in hepatocarcinogenesis in children, can also present in genotype H.",

author = "Utako Oba and Yuhki Koga and Takayuki Hoshina and Aiko Suminoe and Kenji Abe and Makoto Hayashida and Tomoaki Taguchi and Toshiro Hara",

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T1 - An adolescent female having hepatocellular carcinoma associated with hepatitis B virus genotype H with a deletion mutation in the pre-S2 region

AU - Oba, Utako

AU - Koga, Yuhki

AU - Hoshina, Takayuki

AU - Suminoe, Aiko

AU - Abe, Kenji

AU - Hayashida, Makoto

AU - Taguchi, Tomoaki

AU - Hara, Toshiro

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The genotypes of hepatitis B virus (HBV) have a distinct geographical distribution, with HBV genotype H being very rare in East Asia, including Japan. We herein report the case of a 12-year-old Japanese female with hepatocellular carcinoma (HCC) who exhibited HBV genotype H. Notably, the HBV isolated from the patient had a deletion mutation in the pre-S2 region. The genome of HBV genotype H in the patient with HCC has not been analyzed in detail. The deletion mutations in the pre-S2 region, which may play an important role in hepatocarcinogenesis in children, can also present in genotype H.

AB - The genotypes of hepatitis B virus (HBV) have a distinct geographical distribution, with HBV genotype H being very rare in East Asia, including Japan. We herein report the case of a 12-year-old Japanese female with hepatocellular carcinoma (HCC) who exhibited HBV genotype H. Notably, the HBV isolated from the patient had a deletion mutation in the pre-S2 region. The genome of HBV genotype H in the patient with HCC has not been analyzed in detail. The deletion mutations in the pre-S2 region, which may play an important role in hepatocarcinogenesis in children, can also present in genotype H.

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An adolescent female having hepatocellular carcinoma associated with hepatitis B virus genotype H with a deletion mutation in the pre-S2 region

Abstract

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