Amphiregulin regulates the production of human chorionic gonadotropin in trophoblasts

Tatsuya Fukami, Toshiyuki Yoshizato, Shingo Miyamoto, Hiroshi Yagi, Fusanori Yotsumoto, Kazuki Nabeshima, Toru Hachisuga, Masahide Kuroki, Tatsuhiko Kawarabayashi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Aims: The aim of this study was to investigate the significance of epidermal growth factor receptor (EGFR) ligands produced in syncytiotrophoblasts during normal pregnancy. Main methods: We examined the expression of EGFR ligands in human pregnancy by real-time PCR, and analyzed the relationship between EGFR ligands and human chorionic gonadotropin (hCG) or human placental lactogen in amniotic fluid by ELISA. In addition, we also examined the EGFR ligands in syncytiotrophoblasts and the amount of hCG secretion in JAR, JEG3 and BeWo cells in the presence of each EGFR ligand. Key findings: In order to identify possible candidates among the EGFR ligands, we examined the predominant expression of an EGFR ligand in the chorionic villi and amniotic fluid during normal pregnancy, and analyzed the relationship between EGFR ligands and hCG in trophoblastic model cells. Amphiregulin was primarily expressed throughout human pregnancy and stimulated the secretion of hCG, indicating that amphiregulin is a key molecule among EGFR ligands. Significance: Amphiregulin may play a pivotal role in the development or maturation of placenta. Crown

Original languageEnglish
Pages (from-to)796-804
Number of pages9
JournalLife Sciences
Issue number23-24
Publication statusPublished - Jun 5 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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