TY - JOUR
T1 - Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.
AU - Usui, Kazuteru
AU - Fukuda, Mitsuhiro
AU - Aso, Mariko
AU - Suemune, Hiroshi
PY - 2005
Y1 - 2005
N2 - A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.
AB - A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.
UR - http://www.scopus.com/inward/record.url?scp=39049195972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049195972&partnerID=8YFLogxK
U2 - 10.1093/nass/49.1.191
DO - 10.1093/nass/49.1.191
M3 - Meeting Abstract
C2 - 17150698
AN - SCOPUS:39049195972
SN - 1746-8272
SP - 191
EP - 192
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
IS - 49
ER -