TY - JOUR
T1 - Amide proton transfer (APT) magnetic resonance imaging of prostate cancer
T2 - comparison with Gleason scores
AU - Takayama, Yukihisa
AU - Nishie, Akihiro
AU - Sugimoto, Masaaki
AU - Togao, Osamu
AU - Asayama, Yoshiki
AU - Ishigami, Kousei
AU - Ushijima, Yasuhiro
AU - Okamoto, Daisuke
AU - Fujita, Nobuhiro
AU - Yokomizo, Akira
AU - Keupp, Jochen
AU - Honda, Hiroshi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (C), JSPS KAKENHI Grant Number 25461833.
Publisher Copyright:
© 2016, ESMRMB.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objective: To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca). Materials and methods: Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey’s HSD post hoc test. Results: The mean and standard deviation of the APT SIs (%) and ADC values (×10−3 mm2/s) were as follows: GS-6, 2.48 ± 0.59 and 1.16 ± 0.26; GS-7, 5.17 ± 0.66 and 0.92 ± 0.18; GS-8, 2.56 ± 0.85 and 0.86 ± 0.17; GS-9, 1.96 ± 0.75 and 0.85 ± 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups. Conclusion: The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.
AB - Objective: To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca). Materials and methods: Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey’s HSD post hoc test. Results: The mean and standard deviation of the APT SIs (%) and ADC values (×10−3 mm2/s) were as follows: GS-6, 2.48 ± 0.59 and 1.16 ± 0.26; GS-7, 5.17 ± 0.66 and 0.92 ± 0.18; GS-8, 2.56 ± 0.85 and 0.86 ± 0.17; GS-9, 1.96 ± 0.75 and 0.85 ± 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups. Conclusion: The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.
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U2 - 10.1007/s10334-016-0537-4
DO - 10.1007/s10334-016-0537-4
M3 - Article
C2 - 26965511
AN - SCOPUS:84960467828
SN - 0968-5243
VL - 29
SP - 671
EP - 679
JO - Magnetic Resonance Materials in Physics, Biology and Medicine
JF - Magnetic Resonance Materials in Physics, Biology and Medicine
IS - 4
ER -
