TY - JOUR
T1 - Ameliorating effects of cystine and theanine in a cancer cachexia mouse model
AU - Kudamatsu, Hibiki
AU - Kawashiri, Takehiro
AU - Mine, Keisuke
AU - Mori, Kohei
AU - Inoue, Mizuki
AU - Ishida, Haruna
AU - Uchida, Mayako
AU - Tsuchiya, Takashi
AU - Kobayashi, Daisuke
AU - Shimazoe, Takao
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/7
Y1 - 2023/7
N2 - Cachexia is a common cancer complication and is associated with weight loss and anorexia. In this study, we investigated the ameliorating effects of cystine and theanine on cancer cachexia using a mouse model. In mice carrying the colon cancer cell line C-26, there was a suppression of body weight increase and reduction in both internal fat and lower limb muscles. Repeated cystine and theanine administration significantly prevented weight loss, internal fat loss, lower limb muscle loss, and serum IL-6 increase in the cachexia model. These results suggested that cystine and theanine may be effective in ameliorating cancer cachexia.
AB - Cachexia is a common cancer complication and is associated with weight loss and anorexia. In this study, we investigated the ameliorating effects of cystine and theanine on cancer cachexia using a mouse model. In mice carrying the colon cancer cell line C-26, there was a suppression of body weight increase and reduction in both internal fat and lower limb muscles. Repeated cystine and theanine administration significantly prevented weight loss, internal fat loss, lower limb muscle loss, and serum IL-6 increase in the cachexia model. These results suggested that cystine and theanine may be effective in ameliorating cancer cachexia.
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U2 - 10.1016/j.jphs.2023.04.008
DO - 10.1016/j.jphs.2023.04.008
M3 - Article
C2 - 37257943
AN - SCOPUS:85156162478
SN - 1347-8613
VL - 152
SP - 163
EP - 166
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 3
ER -