Ameliorating effects of cystine and theanine in a cancer cachexia mouse model

Hibiki Kudamatsu, Takehiro Kawashiri, Keisuke Mine, Kohei Mori, Mizuki Inoue, Haruna Ishida, Mayako Uchida, Takashi Tsuchiya, Daisuke Kobayashi, Takao Shimazoe

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cachexia is a common cancer complication and is associated with weight loss and anorexia. In this study, we investigated the ameliorating effects of cystine and theanine on cancer cachexia using a mouse model. In mice carrying the colon cancer cell line C-26, there was a suppression of body weight increase and reduction in both internal fat and lower limb muscles. Repeated cystine and theanine administration significantly prevented weight loss, internal fat loss, lower limb muscle loss, and serum IL-6 increase in the cachexia model. These results suggested that cystine and theanine may be effective in ameliorating cancer cachexia.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalJournal of Pharmacological Sciences
Volume152
Issue number3
DOIs
Publication statusPublished - Jul 2023

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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