TY - JOUR
T1 - Aluminum triflate as a powerful catalyst for direct amination of alcohols, including electron-withdrawing group-substituted benzhydrols
AU - Ohshima, Takashi
AU - Ipposhi, Junji
AU - Nakahara, Yasuhito
AU - Shibuya, Ryozo
AU - Mashima, Kazushi
PY - 2012/9/17
Y1 - 2012/9/17
N2 - Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron-withdrawing (F, Br, I, NO 2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf) 3] to afford the corresponding biarylamines in high yield, and the dibromo-substituted product was further transformed into letrozole.
AB - Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron-withdrawing (F, Br, I, NO 2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf) 3] to afford the corresponding biarylamines in high yield, and the dibromo-substituted product was further transformed into letrozole.
UR - http://www.scopus.com/inward/record.url?scp=84865725632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865725632&partnerID=8YFLogxK
U2 - 10.1002/adsc.201200536
DO - 10.1002/adsc.201200536
M3 - Article
AN - SCOPUS:84865725632
SN - 1615-4150
VL - 354
SP - 2447
EP - 2452
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
IS - 13
ER -