Abstract
Existing evidence suggests that patients with schizophrenia may have a deficit in processing facial expressions. However, the neural basis of this processing deficit remains unclear. A total of 20 men diagnosed with chronic schizophrenia and 13 age- and sex-matched controls participated in the study. We investigated visual N170 and P3a components evoked in response to fearful, happy, and sad faces during an emotion discrimination task. Compared with control subjects, patients showed significantly smaller N170 amplitudes bilaterally (P =.04). We found no significant main effect of emotion of the presented faces (fearful, happy, or sad) on N170 amplitude. Patients showed significantly smaller P3a amplitudes in response to fearful (P =.01) and happy (P =.02) faces, but no significant between-group differences were observed for sad faces (P =.22). Moreover, we found no significant P3a modulation effect in response to emotional faces in patients with schizophrenia. Our results suggest that altered P3a modulations to emotional faces may be associated with emotion recognition deficits in patients with schizophrenia.
| Original language | English |
|---|---|
| Pages (from-to) | 215-221 |
| Number of pages | 7 |
| Journal | Clinical EEG and Neuroscience |
| Volume | 51 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1 2020 |
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
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In: Clinical EEG and Neuroscience, Vol. 51, No. 4, 01.07.2020, p. 215-221.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Altered P3a Modulations to Emotional Faces in Male Patients With Chronic Schizophrenia
AU - Onitsuka, Toshiaki
AU - Spencer, Kevin M.
AU - Nakamura, Itta
AU - Hirano, Yoji
AU - Hirano, Shogo
AU - McCarley, Robert W.
AU - Shenton, Martha E.
AU - Niznikiewicz, Margaret A.
N1 - Funding Information: https://orcid.org/0000-0001-6583-6405 Onitsuka Toshiaki 1 https://orcid.org/0000-0002-5500-7627 Spencer Kevin M. 2 Nakamura Itta 1 https://orcid.org/0000-0001-6847-9677 Hirano Yoji 1 2 Hirano Shogo 1 McCarley Robert W. 3 † Shenton Martha E. 3 4 Niznikiewicz Margaret A. 3 1 Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2 Department of Psychiatry, Harvard Medical School and Neural Dynamics Laboratory, VA Boston Healthcare System, Boston, MA, USA 3 Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Boston, MA, USA 4 Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA Toshiaki Onitsuka, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Fukuoka, 8128582, Japan. Email: toshiaki@npsych.med.kyushu-u.ac.jp † Sadly, Dr Robert McCarley passed away in May 2017. 1 2020 1550059419896723 16 11 2018 15 11 2019 26 11 2019 © EEG and Clinical Neuroscience Society (ECNS) 2020 2020 EEG and Clinical Neuroscience Society Existing evidence suggests that patients with schizophrenia may have a deficit in processing facial expressions. However, the neural basis of this processing deficit remains unclear. A total of 20 men diagnosed with chronic schizophrenia and 13 age- and sex-matched controls participated in the study. We investigated visual N170 and P3a components evoked in response to fearful, happy, and sad faces during an emotion discrimination task. Compared with control subjects, patients showed significantly smaller N170 amplitudes bilaterally ( P = .04). We found no significant main effect of emotion of the presented faces (fearful, happy, or sad) on N170 amplitude. Patients showed significantly smaller P3a amplitudes in response to fearful ( P = .01) and happy ( P = .02) faces, but no significant between-group differences were observed for sad faces ( P = .22). Moreover, we found no significant P3a modulation effect in response to emotional faces in patients with schizophrenia. Our results suggest that altered P3a modulations to emotional faces may be associated with emotion recognition deficits in patients with schizophrenia. event-related potentials emotional faces schizophrenia P3a U.S. Department of Veterans Affairs https://doi.org/10.13039/100000738 VA Merit CX000154 japan society for the promotion of science https://doi.org/10.13039/501100001691 KAKENHI FAG6K10217 japan society for the promotion of science https://doi.org/10.13039/501100001691 Strategic Young Researcher Overseas Visits Program National Institute of Mental Health https://doi.org/10.13039/100000025 RO1 MH080187 edited-state corrected-proof typesetter ts1 We thank Nia Cason, PhD, from Edanz Group ( www.edanzediting.com/ac ) for editing a draft of this manuscript. Author Contributions TO contributed to conception and design; contributed to acquisition, analysis, and interpretation; drafted manuscript; gave final approval; agrees to be accountable for all aspects of work ensuring integrity and accuracy. KMS contributed to conception; contributed to analysis and interpretation; critically revised manuscript; gave final approval; agrees to be accountable for all aspects of work ensuring integrity and accuracy. IN contributed to analysis; critically revised manuscript; gave final approval; agrees to be accountable for all aspects of work ensuring integrity and accuracy. YH contributed to interpretation; critically revised manuscript; gave final approval; agrees to be accountable for all aspects of work ensuring integrity and accuracy. SH contributed to interpretation; critically revised manuscript; gave final approval; agrees to be accountable for all aspects of work ensuring integrity and accuracy. RWM contributed to conception and design; contributed to analysis and interpretation; critically revised manuscript; gave final approval; agrees to be accountable for all aspects of work ensuring integrity and accuracy. MES contributed to conception; contributed to interpretation; critically revised manuscript; gave final approval; agrees to be accountable for all aspects of work ensuring integrity and accuracy. MAN contributed to conception and design; contributed to analysis and interpretation; critically revised manuscript; gave final approval; agrees to be accountable for all aspects of work ensuring integrity and accuracy. Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by VA Merit CX000154 (KMS) from the US Department of Veterans Affairs; R01 MH080187 (KMS) and R01 MH093450 (KMS) from the US National Institutes of Health; Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation S2208 (TO), and The Japan Society for the Promotion of Science–KAKENHI FAG6K10217 (TO). The funding sources had no further role in the study design; in the collection, analysis, or interpretation of data; in writing the report; or in the decision to submit the paper for publication. ORCID iDs Toshiaki Onitsuka https://orcid.org/0000-0001-6583-6405 Kevin M. Spencer https://orcid.org/0000-0002-5500-7627 Yoji Hirano https://orcid.org/0000-0001-6847-9677 Funding Information: We thank Nia Cason, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by VA Merit CX000154 (KMS) from the US Department of Veterans Affairs; R01 MH080187 (KMS) and R01 MH093450 (KMS) from the US National Institutes of Health; Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation S2208 (TO), and The Japan Society for the Promotion of Science?KAKENHI FAG6K10217 (TO). The funding sources had no further role in the study design; in the collection, analysis, or interpretation of data; in writing the report; or in the decision to submit the paper for publication. Publisher Copyright: © EEG and Clinical Neuroscience Society (ECNS) 2020.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Existing evidence suggests that patients with schizophrenia may have a deficit in processing facial expressions. However, the neural basis of this processing deficit remains unclear. A total of 20 men diagnosed with chronic schizophrenia and 13 age- and sex-matched controls participated in the study. We investigated visual N170 and P3a components evoked in response to fearful, happy, and sad faces during an emotion discrimination task. Compared with control subjects, patients showed significantly smaller N170 amplitudes bilaterally (P =.04). We found no significant main effect of emotion of the presented faces (fearful, happy, or sad) on N170 amplitude. Patients showed significantly smaller P3a amplitudes in response to fearful (P =.01) and happy (P =.02) faces, but no significant between-group differences were observed for sad faces (P =.22). Moreover, we found no significant P3a modulation effect in response to emotional faces in patients with schizophrenia. Our results suggest that altered P3a modulations to emotional faces may be associated with emotion recognition deficits in patients with schizophrenia.
AB - Existing evidence suggests that patients with schizophrenia may have a deficit in processing facial expressions. However, the neural basis of this processing deficit remains unclear. A total of 20 men diagnosed with chronic schizophrenia and 13 age- and sex-matched controls participated in the study. We investigated visual N170 and P3a components evoked in response to fearful, happy, and sad faces during an emotion discrimination task. Compared with control subjects, patients showed significantly smaller N170 amplitudes bilaterally (P =.04). We found no significant main effect of emotion of the presented faces (fearful, happy, or sad) on N170 amplitude. Patients showed significantly smaller P3a amplitudes in response to fearful (P =.01) and happy (P =.02) faces, but no significant between-group differences were observed for sad faces (P =.22). Moreover, we found no significant P3a modulation effect in response to emotional faces in patients with schizophrenia. Our results suggest that altered P3a modulations to emotional faces may be associated with emotion recognition deficits in patients with schizophrenia.
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UR - http://www.scopus.com/inward/citedby.url?scp=85077632386&partnerID=8YFLogxK
U2 - 10.1177/1550059419896723
DO - 10.1177/1550059419896723
M3 - Article
C2 - 31896289
AN - SCOPUS:85077632386
SN - 1550-0594
VL - 51
SP - 215
EP - 221
JO - Clinical EEG and Neuroscience
JF - Clinical EEG and Neuroscience
IS - 4
ER -