Alteration in the D-amino acid content of the rat pineal gland under anesthesia

K. Hamase, H. Homma, Y. Takigawa, K. Imai

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10 Citations (Scopus)


In a previous report, we showed that the rat pineal gland contains D-leucine (D-Leu) as well as D-aspartic acid (D-Asp). In this communication we report alterations in the content of these D-amino acids during anesthesia. The D-Asp content was significantly increased from 2.8 to 5.0, 4.8 and 5.8 nmol/pineal gland by administration of ether, urethane and pentobarbital, respectively. In contrast, the D-Leu content was decreased by administration of urethane or pentobarbital. The D-Leu content decreased from 4.2 to 2.2 pmol/pineal gland 4 hours after administration of urethane, although the content remained unchanged until 1.5 hours after administration. The content of the L-enantiomers of these amino acids were not affected by anesthesia. The urethane-induced decrease in D-leucine content was almost completely suppressed by a β-agonist, (-)-isoproterenol, whereas the agonist itself had no effect.

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalAmino Acids
Issue number3
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry


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