Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

I. Ito, S. Tanabe, A. Kohda, H. Sugiyama

Research output: Contribution to journalArticlepeer-review

259 Citations (Scopus)


1. Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1‐p‐anisoyl‐2‐pyrrolidinone) was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices. 2. Aniracetam potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. This effect was observed above the concentrations of 0.1 mM. Kainate. N‐methyl‐D‐aspartate and gamma‐aminobutyric acid responses induced in the same oocytes were not affected. 3. The specific potentiation of iQA responses was accompanied by an increase in the conductance change of iQA and alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid (AMPA) responses, but the affinity of receptors for agonist and the ion‐selectivity of the channels (reversal potentials) were not changed. 4. Aniracetam reversibly potentiated the iQA responses recorded intracellularly from the pyramidal cells in the CA1 region of rat hippocampal slices. The excitatory postsynaptic potentials (EPSPs) in Schaffer collateral‐commissural‐CA1 synapses were also potentiated by aniracetam. 5. Population EPSPs recorded in the mossy fibre‐CA3 synapses as well as Schaffer‐commissural synapses were also potentiated by aniracetam. The amplitudes of the potentiation were not changed by the formation of long‐term potentiation.

Original languageEnglish
Pages (from-to)533-543
Number of pages11
JournalThe Journal of Physiology
Issue number1
Publication statusPublished - May 1 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology


Dive into the research topics of 'Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.'. Together they form a unique fingerprint.

Cite this