TY - JOUR
T1 - Allantopyrone E, a rare α-pyrone metabolite from the mangrove derived fungus Aspergillus versicolor
AU - Elsbaey, Marwa
AU - Tanaka, Chiaki
AU - Miyamoto, Tomofumi
N1 - Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - A new α-pyrone derivative, with a rare substitution pattern, was isolated from the solid rice media of the fungal endophyte Aspergillus versicolor associated with the fruit of the mangrove Avicennia marina. It was named allantopyrone E, after allantopyrones C and D. The aforementioned three are the only diaryl-substituted α-pyrones to be reported from nature. The unique structure was elucidated based on one- and two dimensional NMR data as well as high resolution mass spectroscopy. A biosynthetic scheme was proposed for the new compound. Furthermore, allantopyrone E showed cytotoxic effect on HeLa cells with IC50= 50.97 μM.
AB - A new α-pyrone derivative, with a rare substitution pattern, was isolated from the solid rice media of the fungal endophyte Aspergillus versicolor associated with the fruit of the mangrove Avicennia marina. It was named allantopyrone E, after allantopyrones C and D. The aforementioned three are the only diaryl-substituted α-pyrones to be reported from nature. The unique structure was elucidated based on one- and two dimensional NMR data as well as high resolution mass spectroscopy. A biosynthetic scheme was proposed for the new compound. Furthermore, allantopyrone E showed cytotoxic effect on HeLa cells with IC50= 50.97 μM.
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U2 - 10.1080/14786419.2020.1803309
DO - 10.1080/14786419.2020.1803309
M3 - Article
C2 - 32762459
AN - SCOPUS:85089101731
SN - 1478-6419
VL - 36
SP - 760
EP - 764
JO - Natural Product Research
JF - Natural Product Research
IS - 3
ER -