Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats

Tomoharu Masuda; Yasutoshi Hirabara; Yusuke Nakamura; Akiko Chishaki; Mai Tsuruhisa; Masayuki Miyakawa; Kenji Honda; Ryo Saito; Hirotaka Sakamoto; Mitsuhiro Kawata; Yukio Takano

doi:10.1254/jphs.09362SC

Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats

Tomoharu Masuda, Yasutoshi Hirabara, Yusuke Nakamura, Akiko Chishaki, Mai Tsuruhisa, Masayuki Miyakawa, Kenji Honda, Ryo Saito, Hirotaka Sakamoto, Mitsuhiro Kawata, Yukio Takano

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Abstract

We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium-loaded rats and was significantly reduced. This baroreflex sensi-tivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an impor-tant role in baroreflex function.

Original language	English
Pages (from-to)	482-486
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	112
Issue number	4
DOIs	https://doi.org/10.1254/jphs.09362SC
Publication status	Published - Apr 16 2010

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

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Masuda, T., Hirabara, Y., Nakamura, Y., Chishaki, A., Tsuruhisa, M., Miyakawa, M., Honda, K., Saito, R., Sakamoto, H., Kawata, M., & Takano, Y. (2010). Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats. Journal of Pharmacological Sciences, 112(4), 482-486. https://doi.org/10.1254/jphs.09362SC

Masuda, T, Hirabara, Y, Nakamura, Y, Chishaki, A, Tsuruhisa, M, Miyakawa, M, Honda, K, Saito, R, Sakamoto, H, Kawata, M & Takano, Y 2010, 'Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats', Journal of Pharmacological Sciences, vol. 112, no. 4, pp. 482-486. https://doi.org/10.1254/jphs.09362SC

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abstract = "We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium-loaded rats and was significantly reduced. This baroreflex sensi-tivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an impor-tant role in baroreflex function.",

author = "Tomoharu Masuda and Yasutoshi Hirabara and Yusuke Nakamura and Akiko Chishaki and Mai Tsuruhisa and Masayuki Miyakawa and Kenji Honda and Ryo Saito and Hirotaka Sakamoto and Mitsuhiro Kawata and Yukio Takano",

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AU - Masuda, Tomoharu

AU - Hirabara, Yasutoshi

AU - Nakamura, Yusuke

AU - Chishaki, Akiko

AU - Tsuruhisa, Mai

AU - Miyakawa, Masayuki

AU - Honda, Kenji

AU - Saito, Ryo

AU - Sakamoto, Hirotaka

AU - Kawata, Mitsuhiro

AU - Takano, Yukio

PY - 2010/4/16

Y1 - 2010/4/16

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AB - We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium-loaded rats and was significantly reduced. This baroreflex sensi-tivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an impor-tant role in baroreflex function.

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Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats

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