Alcohol consumption and severity of angiographically determined coronary artery disease in Japanese men and women

Ying Liu, Heizo Tanaka, Shizuka Sasazuki, Kouichi Yoshimasu, Hiroko Kodama, Masakazu Washio, Keitaro Tanaka, Shoji Tokunaga, Suminori Kono, Hidekazu Arai, Samon Koyanagi, Koji Hiyamuta, Yoshitaka Doi, Tomoki Kawano, Osamu Nakagaki, Kazuyuki Takada, Takanobu Nii, Kazuyuki Shirai, Munehito Ideishi, Kikuo ArakawaMasahiro Mohri, Akira Takeshita

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The relation of alcohol consumption to the severity of coronary atherosclerosis was examined among 323 men and 220 women who underwent coronary arteriography. Severity of coronary atherosclerosis was assessed by the number of vessels obstructed ≥75% in diameter and Gensini's severity score. Alcohol consumption was divided into 5 categories in men (never, past, 1-24, 25-49, and ≥50 ml per day) and 3 categories in women (never, past, and current). Among men, odds ratios of severe stenosis (multiple-vessel disease or Gensini's score >15) decreased substantially and significantly in all current drinking categories but without dose-response effect. There was a weak, inverse association of current alcohol consumption with one-vessel disease, but not with moderate stenosis in terms of Gensini's score (≤15). Past drinkers showed a fairly large, but statistically nonsignificant, decrease in the odds ratios of not only severe stenosis but also of moderate stenosis. Among women, current drinkers showed a small, statistically nonsignificant decrease in the risk of severe stenosis in terms of Gensini's score. These associations with alcohol use did not change after adjustment for known coronary risk factors. The present findings add to evidence that alcohol drinking confers protection against coronary atherosclerosis.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
Issue number1
Publication statusPublished - May 2001

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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