Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

Chriselle D. Braganza; Chihiro Motozono; Koh Hei Sonoda; Sho Yamasaki; Kensuke Shibata; Mattie S.M. Timmer; Bridget L. Stocker

doi:10.1039/d0cc00247j

Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

Chriselle D. Braganza, Chihiro Motozono, Koh Hei Sonoda, Sho Yamasaki, Kensuke Shibata, Mattie S.M. Timmer, Bridget L. Stocker

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified. This journal is

Original language	English
Pages (from-to)	5291-5294
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	39
DOIs	https://doi.org/10.1039/d0cc00247j
Publication status	Published - May 14 2020

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified. This journal is ",

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T1 - Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

AU - Braganza, Chriselle D.

AU - Motozono, Chihiro

AU - Sonoda, Koh Hei

AU - Yamasaki, Sho

AU - Shibata, Kensuke

AU - Timmer, Mattie S.M.

AU - Stocker, Bridget L.

PY - 2020/5/14

Y1 - 2020/5/14

N2 - Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified. This journal is

AB - Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified. This journal is

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JO - Chemical Communications

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Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

Abstract

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