TY - JOUR
T1 - Aggregation of a double hydrophilic block glycopolymer
T2 - The effect of block polymer ratio
AU - Oh, Takahiro
AU - Hoshino, Yu
AU - Miura, Yoshiko
N1 - Funding Information:
This work was supported by a JSPS KAKENHI Grant Number JP20H05230, JP20H04825, JP19K22971 and JP19H02766.
Publisher Copyright:
© 2020 The Royal Society of Chemistry.
PY - 2020/11/28
Y1 - 2020/11/28
N2 - Double hydrophilic block glycopolymers (DHBGs) composed of glycopolymers and polyethylene glycol (PEG) aggregate in aqueous solution. However, there are no guidelines to direct and design DHBG aggregation. Herein, we investigated the effect of the ratio of glycopolymer length to PEG length on the structure, and report that structure size could be influenced by the block polymer ratio. Nine kinds of DHBG with different glycopolymers and PEG lengths were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The aggregation capability of DHBG was investigated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). In all cases, the DHBGs formed the spherical structures, even when the PEG and glycopolymer lengths were quite different. The size of the structure was controlled by the ratio of the PEG length to the glycopolymer length. The aggregation of the DHBGs was induced by hydrogen bonding between the sugar moieties. The aggregation of the DHBG was affected by temperature and concentration.
AB - Double hydrophilic block glycopolymers (DHBGs) composed of glycopolymers and polyethylene glycol (PEG) aggregate in aqueous solution. However, there are no guidelines to direct and design DHBG aggregation. Herein, we investigated the effect of the ratio of glycopolymer length to PEG length on the structure, and report that structure size could be influenced by the block polymer ratio. Nine kinds of DHBG with different glycopolymers and PEG lengths were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The aggregation capability of DHBG was investigated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). In all cases, the DHBGs formed the spherical structures, even when the PEG and glycopolymer lengths were quite different. The size of the structure was controlled by the ratio of the PEG length to the glycopolymer length. The aggregation of the DHBGs was induced by hydrogen bonding between the sugar moieties. The aggregation of the DHBG was affected by temperature and concentration.
UR - http://www.scopus.com/inward/record.url?scp=85096457161&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096457161&partnerID=8YFLogxK
U2 - 10.1039/d0tb02093a
DO - 10.1039/d0tb02093a
M3 - Article
C2 - 33112358
AN - SCOPUS:85096457161
SN - 2050-750X
VL - 8
SP - 10101
EP - 10107
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 44
ER -