Age-related effects of three inhalational anesthetics at one minimum alveolar concentration on electroencephalogram waveform

Masanori Tsukamoto, Shiori Taura, Hitoshi Yamanaka, Takashi Hitosugi, Yoshifumi Kawakubo, Takeshi Yokoyama

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background: The characteristics of electroencephalogram (EEG) profiles under general anesthesia may depend on age and type of anesthetic. Aim: This study investigated age-related differences in EEG waveforms between three inhalational anesthetics used at the same minimum alveolar concentration (MAC), which indicates the level of analgesia. Methods: Patients with American Society of Anesthesiologists physical status I–II were divided into three groups according to age: pediatric (≦ 15 years); adult (16–64 years); and elderly (≧ 65 years). Each group was divided into three subgroups according to the inhalational anesthetic used: sevoflurane, isoflurane, and desflurane. Anesthesia was maintained at 1 MAC, followed by assessment of 95% spectral edge frequency (SEF95) values and amplitude of EEG waveform. Results: The 3 age groups comprised a total of 180 patients. The mean (± SD) EEG waveform amplitude and SEF95 values for sevoflurane in the pediatric, adult, and elderly age groups, respectively, were: 32.9 ± 2.9 µV and 16.7 ± 2.4 Hz; 16.4 ± 3.6 µV and 12.2 ± 1.3 Hz; and 11.0 ± 2.1 µV and 13.6 ± 1.6 Hz. EEG waveform amplitude and SEF95 values were significantly higher in the pediatric group than in the other groups. SEF95 value was higher in the elderly group than in the adult group. Similar results were obtained for isoflurane and desflurane. Conclusion: The amplitude of the EEG waveform and SEF95 values varied with age, even at the same analgesic state in patients under general anesthesia. This age-dependent change in EEG waveform was observed for all three inhalational anesthetics, and should be considered in procedures requiring general anesthesia.

Original languageEnglish
Pages (from-to)1857-1864
Number of pages8
JournalAging Clinical and Experimental Research
Issue number9
Publication statusPublished - Sept 1 2020

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology


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