Affected sib pair method for searching major gene in multifactorial disease

Norikazu Yasuda, Takehiko Sasazuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The affected sib pair method to detect the effect of HLA-linked disease genes has been explained from a practical viewpoint. It is based on the assumption that HLA haplotypes as marker are used to trace the inheritance pattern of closely linked disease susceptibility genes. Looking at families in which two or more siblings had disease in question, the nonrandom zygotic assortment of HLA haplotypes would be a demonstration of disease gene. Application of affected sib pair method to Graves' disease had delineated that two genes, HLA-lined and Gm-linked, are responsible for manifestation of the disease as recessive inheritance with high penetrance.

Original languageEnglish
Pages (from-to)295-311
Number of pages17
JournalThe Japanese Journal of Human Genetics
Issue number4
Publication statusPublished - Dec 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)


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