TY - JOUR
T1 - Aerobic oxidation of isoprene glycol with platinum-bismuth nanoparticles catalysts supported on metal oxides
AU - Kawai, Yasutaka
AU - Haruguchi, Kazuki
AU - Sumikawa, Keisei
AU - Kawada, Mai
AU - Yamamoto, Eiji
AU - Murayama, Haruno
AU - Tokunaga, Makoto
N1 - Funding Information:
This work was financially supported by Kuraray Co., LTD . We appreciate Osamu Nakayama (Kuraray Co., Ltd.) for the valuable discussion and Ichiro Mihara (Kuraray Co., Ltd.) for the XPS measurements. The TEM observations were performed at the Ultramicroscopy Research Center, Kyushu University.
Funding Information:
This work was financially supported by Kuraray Co. LTD. We appreciate Osamu Nakayama (Kuraray Co. Ltd.) for the valuable discussion and Ichiro Mihara (Kuraray Co. Ltd.) for the XPS measurements. The TEM observations were performed at the Ultramicroscopy Research Center, Kyushu University.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/8/5
Y1 - 2022/8/5
N2 - β-Hydroxy β-methylbutyric acid (HMB) is expected as a promising therapeutic agent or a supplement. For industrial production of HMB, Pt-catalyzed aerobic oxidation of isoprene glycol is a potent synthetic method. However, the previous report using Pt-Bi catalyst supported on active carbon suffered from low tolerance to high substrate concentration conditions, which leads to low volumetric productivity. Herein, we report aerobic oxidation of isoprene glycol using Pt-Bi catalysts supported on ZrO2 or TiO2, showing high tolerance to the high substrate concentration conditions. In addition, these catalysts exhibited high recyclability. Scanning transmission electron microscopy analyses suggested the Pt-Bi species supported on ZrO2 or TiO2 are less likely to aggregate than those supported on activated carbon. Additionally, these metal oxides supported catalysts showed lower metal leaching than the carbon supported catalysts. Besides, the results of the various control experiments indicated the prevention of dehydration of an aldehyde intermediate is important for further improvement.
AB - β-Hydroxy β-methylbutyric acid (HMB) is expected as a promising therapeutic agent or a supplement. For industrial production of HMB, Pt-catalyzed aerobic oxidation of isoprene glycol is a potent synthetic method. However, the previous report using Pt-Bi catalyst supported on active carbon suffered from low tolerance to high substrate concentration conditions, which leads to low volumetric productivity. Herein, we report aerobic oxidation of isoprene glycol using Pt-Bi catalysts supported on ZrO2 or TiO2, showing high tolerance to the high substrate concentration conditions. In addition, these catalysts exhibited high recyclability. Scanning transmission electron microscopy analyses suggested the Pt-Bi species supported on ZrO2 or TiO2 are less likely to aggregate than those supported on activated carbon. Additionally, these metal oxides supported catalysts showed lower metal leaching than the carbon supported catalysts. Besides, the results of the various control experiments indicated the prevention of dehydration of an aldehyde intermediate is important for further improvement.
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U2 - 10.1016/j.apcata.2022.118781
DO - 10.1016/j.apcata.2022.118781
M3 - Article
AN - SCOPUS:85135078404
SN - 0926-860X
VL - 643
JO - Applied Catalysis A: General
JF - Applied Catalysis A: General
M1 - 118781
ER -