Advanced surgical strategy for giant mediastinal germ cell tumor in children

Shigehisa Fumino, Kohei Sakai, Mayumi Higashi, Shigeyoshi Aoi, Taizo Furukawa, Masaaki Yamagishi, Masayoshi Inoue, Tomoko Iehara, Hajime Hosoi, Tatsuro Tajiri

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose Giant mediastinal germ cell tumor (MGCT) requires a well-planned advanced surgical approach. We retrospectively reviewed our surgical strategy for giant MGCT. Methods Five children (median age, 5 years) with giant MGCT were treated in our institute from 2012 to 2016. Results The initial diagnosis was made by tumor markers and image inspection in all cases. Benign teratomas (2 girls) and malignancies (3 boys) were treated with upfront surgery and radical tumorectomy after neo-adjuvant chemotherapy, respectively. After detailed 3D-CT, radical tumor excision was performed supported by a skilled pediatric cardiovascular surgeon. The basic approach was as follows: under cardiopulmonary support (CPS) or with CPS on standby, via median sternotomy, the pericardium and phrenic nerve were resected en bloc with the tumor, followed by diaphragmatic plication. Open biopsy was performed via lateral thoracotomy in 1 patient who showed dense adhesion and fistula formation in the lung; lobectomy via hemi-clamshell incision was required. No deaths or severe sequelae occurred in this series. Conclusions Resectability is the most important predictor of outcomes for MGCTs. Preoperative 3D-CT and CPS can enable complete resection and ensure surgical safety. Well-functioned surgical team is critical success factor in such advanced surgery.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalJournal of Pediatric Surgery Case Reports
Publication statusPublished - Dec 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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