Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan

Kunihisa Kobayashi, Toyoshi Inoguchi, Noriyuki Sonoda, Naotaka Sekiguchi, Hajime Nawata

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The aim of this study was to test the possibility that adiponectin has an antiatherogenic effect through the inhibition of LDL binding to proteoglycans, an initial event in atherogenesis. Both full-length and globular adiponectin inhibited LDL binding in a dose-dependent manner. Both types of adiponectin bound to biglycan in a dose-dependent manner. Immunoprecipitation and immunoblotting analysis showed interaction of full-length adiponectin with LDL. Pretreatment of biglycan with globular adiponectin prior to LDL addition diminished the inhibitory effect, while pretreatment with full-length adiponectin retained the effect. This is a new antiatherogenic property that appears independent of the receptor-mediated hormonal action of adiponectin.

Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - Sept 16 2005

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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