Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase

Hironori Kitaguchi; Kei Ohkubo; Seiji Ogo; Shunichi Fukuzumi

doi:10.1039/b515004c

Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase

Hironori Kitaguchi, Kei Ohkubo, Seiji Ogo, Shunichi Fukuzumi

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A simple additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with cumylperoxyl radical, which is expressed by the additive contributions of the reactivity of active hydrogens from the 1,4-pentadiene subunit and those of the allylic subunit; the kinetic isotope effect on the hydrogen transfer reactions (KIE = 6.1) is significantly smaller than that observed for lipoxygenase (KIE = 81).

Original language	English
Pages (from-to)	979-981
Number of pages	3
Journal	Chemical Communications
Issue number	9
DOIs	https://doi.org/10.1039/b515004c
Publication status	Published - Jan 1 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b515004c

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abstract = "A simple additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with cumylperoxyl radical, which is expressed by the additive contributions of the reactivity of active hydrogens from the 1,4-pentadiene subunit and those of the allylic subunit; the kinetic isotope effect on the hydrogen transfer reactions (KIE = 6.1) is significantly smaller than that observed for lipoxygenase (KIE = 81).",

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AU - Fukuzumi, Shunichi

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Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase

Abstract

All Science Journal Classification (ASJC) codes

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