TY - JOUR
T1 - Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9
AU - Aoki, Takatoshi
AU - Miyamoto, Toshihiro
AU - Yoshida, Shuro
AU - Yamamoto, Asataro
AU - Yamauchi, Takuji
AU - Yoshimoto, Goichi
AU - Mori, Yasuo
AU - Kamezaki, Kenjiro
AU - Iwasaki, Hiromi
AU - Takenaka, Katsuto
AU - Harada, Naoki
AU - Nagafuji, Koji
AU - Teshima, Takanori
AU - Akashi, Koichi
N1 - Funding Information:
Acknowledgments We thank the medical and nursing staff working on the Fukuoka Blood and Marrow Transplantation Group. This work was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology in Japan and from the Takeda Science Foundation, Osaka, Japan to T.M.
PY - 2009/12
Y1 - 2009/12
N2 - We report a 29-year-old Japanese male with acute myelogenous leukemia (AML)-M4 with a cryptic t(7;11)(p15;p15), in which a chimeric NUP98-HOXA9 fusion was detected by polymerase chain reaction analysis and a chromosomal analysis showed 46,XY. The patient received intensive chemotherapy and underwent autologous stem cell transplantation, and remission was confirmed by the disappearance of NUP98-HOXA9. However, 6 months after transplantation, the patient relapsed; NUP98-HOXA9 was detected again and karyotypic analysis revealed 46,XY, t(1;21)(p32;q22). Fluorescent in situ hybridization (FISH) analysis using an AML1-ETO translocation dual probe, showed that the 21q22 breakpoint involved AML1 locus. A retrospective FISH analysis showed that t(1;21) was absent at onset. This is the first reported case with AML who had a cryptic t(7;11)(p15;p15), and additionally acquired t(1;21)(p32;q22) at relapse.
AB - We report a 29-year-old Japanese male with acute myelogenous leukemia (AML)-M4 with a cryptic t(7;11)(p15;p15), in which a chimeric NUP98-HOXA9 fusion was detected by polymerase chain reaction analysis and a chromosomal analysis showed 46,XY. The patient received intensive chemotherapy and underwent autologous stem cell transplantation, and remission was confirmed by the disappearance of NUP98-HOXA9. However, 6 months after transplantation, the patient relapsed; NUP98-HOXA9 was detected again and karyotypic analysis revealed 46,XY, t(1;21)(p32;q22). Fluorescent in situ hybridization (FISH) analysis using an AML1-ETO translocation dual probe, showed that the 21q22 breakpoint involved AML1 locus. A retrospective FISH analysis showed that t(1;21) was absent at onset. This is the first reported case with AML who had a cryptic t(7;11)(p15;p15), and additionally acquired t(1;21)(p32;q22) at relapse.
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U2 - 10.1007/s12185-008-0198-9
DO - 10.1007/s12185-008-0198-9
M3 - Article
C2 - 19005624
AN - SCOPUS:64249140314
SN - 0925-5710
VL - 88
SP - 571
EP - 574
JO - International journal of hematology
JF - International journal of hematology
IS - 5
ER -