Acute ‘bilineal‐biphenotypic’ leukaemia

Koichi Akashi, Tsunefumi Shibuya, Mine Harada, Eiji Morioka, Koichi Oshima, Nobuhiro Kimura, Morishige Takeshita, Mamoru Kurokawa, Masahiro Kikuchi, Yoshiyuki Niho

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20 Citations (Scopus)


We describe a unique case of hybrid leukaemia with bilineal and biphenotypic features. The coexistence of lymphoblasts and monoblasts was determined morphologically and cytochemically. Immunofluorescence and immunohistochemical analysis revealed that each blast population had both T lymphoid (CD2, cytoplasmic CD3) and myeloid (CD11, CD13, CD15) markers. Southern blot analysis of DNA extracted from the lymph node biopsy demonstrated the presence of monoclonal rearrangement of the TcR‐Cβ gene. Cytogenetic analysis of the bone marrow cells showed a karyotype of 48, XY, 7q + in all of the metaphases examined. These observations are suggestive of a monoclonal origin for these two distinct blast populations.

Original languageEnglish
Pages (from-to)402-407
Number of pages6
JournalBritish Journal of Haematology
Issue number4
Publication statusPublished - Apr 1990

All Science Journal Classification (ASJC) codes

  • Hematology


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