Active infective endocarditis - Management and risk analysis of hospital death from 24 years' experience

Makoto Hanai, Kazuhiro Hashimoto, Kenoh Mashiko, Tatsuumi Sasaki, Yoshimasa Sakamoto, Kazuaki Shiratori, Kei Tanaka, Michio Yoshitake, Hirokuni Naganuma, Gen Shinohara

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Background: This study was performed to identify risk factors for hospital death in patients with acute and active infective endocarditis (AAIE) after surgical intervention. Methods and Results: From 1980 to 2004, 94 patients underwent surgery for AAIE (age range, 3-77 years; 76% males). Congestive heart failure (CHF) was present in 44 patients, as well as vegeta tions in 64, septicemia in 16, abscesses in 17, and emboli in 22; 16 patients had prosthetic valve endocarditis. Streptococci were the most common bacteria (34 patients), followed by staphylococci (17 patients). Mechanical valves were selected for 73 patients and bioprosthetic valves for 16. Mitral valve plasty was performed in 4 patients. Aortic root or aorto-mitral discontinuity was repaired in 17 patients, including Manouguian's double valve replacement in 6 and aortic root replacement in 4. Overall hospital mortality was 15% (14 patients). Univariate analysis identified CHF (p=0.016), abscess (p=0.014), and prosthetic valve endocarditis (p=0.043) as risk factors. However, multivariate analysis only identified CHF (p=0.019) as an independent risk factor. Conclusion: In AAIE, early surgical intervention is advisable before the occurrence of complications such as root abscess and CHF, particularly before the onset of CHF.

Original languageEnglish
Pages (from-to)2062-2068
Number of pages7
JournalCirculation Journal
Issue number12
Publication statusPublished - 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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