TY - JOUR
T1 - Active and passive smoking and risk of Parkinson's disease
AU - Tanaka, K.
AU - Miyake, Y.
AU - Fukushima, W.
AU - Sasaki, S.
AU - Kiyohara, C.
AU - Tsuboi, Y.
AU - Yamada, T.
AU - Oeda, T.
AU - Miki, T.
AU - Kawamura, N.
AU - Sakae, N.
AU - Fukuyama, H.
AU - Hirota, Y.
AU - Nagai, M.
PY - 2010/12
Y1 - 2010/12
N2 - Objective - To assess the association between active and passive smoking and the risk of Parkinson's disease (PD), a case-control study with 249 PD patients and 369 controls was carried out in Japan.Methods - Information on smoking was obtained through a self-administered questionnaire. Adjustment was made for age, sex, region of residence, educational level, and occupational exposure.Results - Ever having smoked cigarettes was associated with a reduced risk of PD [adjusted odds ratio = 0.38; 95% confidence interval (CI): 0.24-0.59]. Risk for former smokers was intermediate between the high risk for never smokers and the low risk for current smokers. Adjusted odds ratios for former and current smokers were 0.51 (95% CI: 0.32-0.82) and 0.12 (95% CI: 0.05-0.26), respectively. There was an inverse dose-response gradient with pack-years smoked. No significant association was detected for passive smoking exposure.Conclusion - Our results appear to confirm data from previous epidemiological studies.
AB - Objective - To assess the association between active and passive smoking and the risk of Parkinson's disease (PD), a case-control study with 249 PD patients and 369 controls was carried out in Japan.Methods - Information on smoking was obtained through a self-administered questionnaire. Adjustment was made for age, sex, region of residence, educational level, and occupational exposure.Results - Ever having smoked cigarettes was associated with a reduced risk of PD [adjusted odds ratio = 0.38; 95% confidence interval (CI): 0.24-0.59]. Risk for former smokers was intermediate between the high risk for never smokers and the low risk for current smokers. Adjusted odds ratios for former and current smokers were 0.51 (95% CI: 0.32-0.82) and 0.12 (95% CI: 0.05-0.26), respectively. There was an inverse dose-response gradient with pack-years smoked. No significant association was detected for passive smoking exposure.Conclusion - Our results appear to confirm data from previous epidemiological studies.
UR - http://www.scopus.com/inward/record.url?scp=77956664095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956664095&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0404.2010.01327.x
DO - 10.1111/j.1600-0404.2010.01327.x
M3 - Article
C2 - 20175761
AN - SCOPUS:77956664095
SN - 0001-6314
VL - 122
SP - 377
EP - 382
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
IS - 6
ER -