Activation of EL-4 T-cells by irradiation with atmospheric oxygen plasma

Sitti Subaedah, Haruka Uematsu, Nobuya Hayashi

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4 Citations (Scopus)


The activation of EL-4 T-cells is investigated when the T-cells are sensitized with monoclonal antibodies against CD3/CD28 followed by irradiation with atmospheric oxygen plasma. The proliferation of anti-CD3/CD28-sensitized EL-4 T-cells was evaluated as a function of the oxygen plasma irradiation duration. The plasma irradiation promotes cell proliferation: when plasma irradiation was applied to sensitize T-cells for 40 s, the cell number increased by five times over 24 h compared with that in a cell population that was not exposed to irradiation. Also, the plasma irradiation increases the production of interferon gamma in T-cells by a factor of two. Gene expression analysis of T-cell supports results of the proliferation and the immune function enhancements.

Original languageEnglish
Article numberSJJF03
JournalJapanese journal of applied physics
Issue numberSJ
Publication statusPublished - Jun 1 2020

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physics and Astronomy(all)


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