Activation and alteration of base selectivity by metal cations in the functionality-transfer reaction for RNA modification

Kazumitsu Onizuka; Yosuke Taniguchi; Shigeki Sasaki

doi:10.1021/bc100131j

Activation and alteration of base selectivity by metal cations in the functionality-transfer reaction for RNA modification

Kazumitsu Onizuka, Yosuke Taniguchi, Shigeki Sasaki

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Previously, we reported that the 2-methylidene-1,3-diketone unit of 6-thioguanosine transferred selectively to the amino group of cytosine at pH 7.0 and that its selectivity was changed to the guanine base at pH 9.6. In this study, it was found that the functionality-transfer reaction enhanced selectivity for the guanine base in the presence of divalent transition metal cations such as Ni²⁺ and Co²⁺ at pH 7.4.

Original language	English
Pages (from-to)	1508-1512
Number of pages	5
Journal	Bioconjugate Chemistry
Volume	21
Issue number	8
DOIs	https://doi.org/10.1021/bc100131j
Publication status	Published - Aug 18 2010

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomedical Engineering
Pharmacology
Pharmaceutical Science
Organic Chemistry

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AU - Sasaki, Shigeki

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AB - Previously, we reported that the 2-methylidene-1,3-diketone unit of 6-thioguanosine transferred selectively to the amino group of cytosine at pH 7.0 and that its selectivity was changed to the guanine base at pH 9.6. In this study, it was found that the functionality-transfer reaction enhanced selectivity for the guanine base in the presence of divalent transition metal cations such as Ni2+ and Co2+ at pH 7.4.

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Activation and alteration of base selectivity by metal cations in the functionality-transfer reaction for RNA modification

Abstract

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