Acetate-producing bifidobacteria protect the host from enteropathogenic infection via carbohydrate transporters

Shinji Fukuda, Hidehiro Toh, Todd D. Taylor, Hiroshi Ohno, Masahira Hattori

Research output: Contribution to journalArticlepeer-review

163 Citations (Scopus)


The human gut harbors a large and diverse community of commensal bacteria. Among them, Bifidobacterium is known to exhibit various probiotic effects including protection of hosts from infectious diseases. We recently discovered that genes encoding an ATPbinding- cassette-type carbohydrate transporter present in certain bifidobacteria contribute to protecting gnotobiotic mice from death induced by enterohemorrhagic Escherichia coli O157:H7. We elucidated the molecular mechanism on lethal infection in mice associated with several bifidobacterial strains by a multiomics approach combining genomics, transcriptomics and metabolomics. The combined data clearly show that acetate produced by protective bifidobacteria acts in vivo to promote defense functions of the host epithelial cells and thereby protects the host from lethal infection. As demonstrated here, our multi-omics approach provides a powerful strategy for evaluation of host-microbial interactions in the complex gut ecosystem.

Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalGut Microbes
Issue number5
Publication statusPublished - 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases


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