TY - JOUR
T1 - ACE1 polymorphism and progression of SARS
AU - Itoyama, Satoru
AU - Keicho, Naoto
AU - Quy, Tran
AU - Phi, Nguyen Chi
AU - Long, Hoang Thuy
AU - Ha, Le Dang
AU - Ban, Vo Van
AU - Ohashi, Jun
AU - Hijikata, Minako
AU - Matsushita, Ikumi
AU - Kawana, Akihiko
AU - Yanai, Hideki
AU - Kirikae, Teruo
AU - Kuratsuji, Tadatoshi
AU - Sasazuki, Takehiko
N1 - Funding Information:
The authors thank Dr. Nguyen Le Hang, Ms. Pham Thi Phuong Thuy, and Ms. Nguyen Thi Thu Ha for their help in management and coordination of this study in Vietnam and Drs. Shuzo Kanagawa and Yukihiko Ishizaka in Japan. The authors also thank Ms. Kazuko Tanabe for her critical reading of the manuscript. This work was supported by Special Coordination Funds for Promoting Science and Technology and by a grant for International Health Cooperation Research (14C-9) from the Ministry of Health, Labour and Welfare in 2003.
PY - 2004/10/22
Y1 - 2004/10/22
N2 - We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p = 0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.
AB - We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p = 0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.
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U2 - 10.1016/j.bbrc.2004.08.208
DO - 10.1016/j.bbrc.2004.08.208
M3 - Article
C2 - 15381116
AN - SCOPUS:4544366685
SN - 0006-291X
VL - 323
SP - 1124
EP - 1129
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -