Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis

Akira Kondo; Toru Iwaki; Jun Tateishi; Kohji Kirimoto; Tadao Morimoto; Ichirou Oomura

doi:10.1111/j.1440-1819.1986.tb03184.x

Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis

Akira Kondo, Toru Iwaki, Jun Tateishi, Kohji Kirimoto, Tadao Morimoto, Ichirou Oomura

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Abstract: We report a case of sporadic amyotrophic lateral sclerosis (ALS) characterized by a marked accumulation of neurofilaments in the cytoplasm of neurons. The neurofilament was identified by immunohistochemical and electron microscopic studies. The distribution of the accumulation in this case was unique, not only in the motoneurons of the anterior horn but also in the neurons of the other areas of the spinal gray matter, some nuclei in the brain stem, pontine reticular formation, substantia nigra, dentate nucleus in the cerebellum and pyramidal cells in the motor cortex. These observations shed light on the pathogenesis of ALS.

Original language	English
Pages (from-to)	677-684
Number of pages	8
Journal	Psychiatry and clinical neurosciences
Volume	40
Issue number	4
DOIs	https://doi.org/10.1111/j.1440-1819.1986.tb03184.x
Publication status	Published - Dec 1986
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Neurology
Clinical Neurology
Psychiatry and Mental health

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10.1111/j.1440-1819.1986.tb03184.x

Cite this

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title = "Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis",

abstract = "Abstract: We report a case of sporadic amyotrophic lateral sclerosis (ALS) characterized by a marked accumulation of neurofilaments in the cytoplasm of neurons. The neurofilament was identified by immunohistochemical and electron microscopic studies. The distribution of the accumulation in this case was unique, not only in the motoneurons of the anterior horn but also in the neurons of the other areas of the spinal gray matter, some nuclei in the brain stem, pontine reticular formation, substantia nigra, dentate nucleus in the cerebellum and pyramidal cells in the motor cortex. These observations shed light on the pathogenesis of ALS.",

author = "Akira Kondo and Toru Iwaki and Jun Tateishi and Kohji Kirimoto and Tadao Morimoto and Ichirou Oomura",

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T1 - Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis

AU - Kondo, Akira

AU - Iwaki, Toru

AU - Tateishi, Jun

AU - Kirimoto, Kohji

AU - Morimoto, Tadao

AU - Oomura, Ichirou

PY - 1986/12

Y1 - 1986/12

N2 - Abstract: We report a case of sporadic amyotrophic lateral sclerosis (ALS) characterized by a marked accumulation of neurofilaments in the cytoplasm of neurons. The neurofilament was identified by immunohistochemical and electron microscopic studies. The distribution of the accumulation in this case was unique, not only in the motoneurons of the anterior horn but also in the neurons of the other areas of the spinal gray matter, some nuclei in the brain stem, pontine reticular formation, substantia nigra, dentate nucleus in the cerebellum and pyramidal cells in the motor cortex. These observations shed light on the pathogenesis of ALS.

AB - Abstract: We report a case of sporadic amyotrophic lateral sclerosis (ALS) characterized by a marked accumulation of neurofilaments in the cytoplasm of neurons. The neurofilament was identified by immunohistochemical and electron microscopic studies. The distribution of the accumulation in this case was unique, not only in the motoneurons of the anterior horn but also in the neurons of the other areas of the spinal gray matter, some nuclei in the brain stem, pontine reticular formation, substantia nigra, dentate nucleus in the cerebellum and pyramidal cells in the motor cortex. These observations shed light on the pathogenesis of ALS.

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Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis

Abstract

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