Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis

Akira Kondo, Toru Iwaki, Jun Tateishi, Kohji Kirimoto, Tadao Morimoto, Ichirou Oomura

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Abstract: We report a case of sporadic amyotrophic lateral sclerosis (ALS) characterized by a marked accumulation of neurofilaments in the cytoplasm of neurons. The neurofilament was identified by immunohistochemical and electron microscopic studies. The distribution of the accumulation in this case was unique, not only in the motoneurons of the anterior horn but also in the neurons of the other areas of the spinal gray matter, some nuclei in the brain stem, pontine reticular formation, substantia nigra, dentate nucleus in the cerebellum and pyramidal cells in the motor cortex. These observations shed light on the pathogenesis of ALS.

Original languageEnglish
Pages (from-to)677-684
Number of pages8
JournalPsychiatry and clinical neurosciences
Issue number4
Publication statusPublished - Dec 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


Dive into the research topics of 'Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis'. Together they form a unique fingerprint.

Cite this