TY - JOUR
T1 - Accumulation of MDM2 in pleomorphic xanthoastrocytomas
AU - Matsumoto, Kenichi
AU - Suzuki, Satoshi O.
AU - Fukui, Masashi
AU - Iwaki, Toru
PY - 2004/6
Y1 - 2004/6
N2 - The molecular genetic basis and the tumorigenic mechanism of pleomorphic xanthoastrocytoma (PXA) still remain to be elucidated. The amplification of the mdm2 gene and accumulation of the MDM2 protein, which is considered to be one of the major cellular regulators of p53-mediated cell growth control, were studied in eight specimens of PXA obtained from five patients. All of the PXA samples showed at least focal immunopositivity for MDM2. However, none of the samples showed mdm2 gene amplification. These results suggest that accumulation of MDM2 without gene amplification may be one of the major molecular events occurring in the tumorigenesis of PXA.
AB - The molecular genetic basis and the tumorigenic mechanism of pleomorphic xanthoastrocytoma (PXA) still remain to be elucidated. The amplification of the mdm2 gene and accumulation of the MDM2 protein, which is considered to be one of the major cellular regulators of p53-mediated cell growth control, were studied in eight specimens of PXA obtained from five patients. All of the PXA samples showed at least focal immunopositivity for MDM2. However, none of the samples showed mdm2 gene amplification. These results suggest that accumulation of MDM2 without gene amplification may be one of the major molecular events occurring in the tumorigenesis of PXA.
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U2 - 10.1111/j.1440-1827.2004.01637.x
DO - 10.1111/j.1440-1827.2004.01637.x
M3 - Article
C2 - 15144396
AN - SCOPUS:3042651137
SN - 1320-5463
VL - 54
SP - 387
EP - 391
JO - Pathology International
JF - Pathology International
IS - 6
ER -