TY - JOUR
T1 - Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues
AU - Hassan, Nur Mohammad Monsur
AU - Hamada, Jun Ichi
AU - Murai, Taichi
AU - Seino, Akihusa
AU - Takahashi, Yoko
AU - Tada, Mitsuhiro
AU - Zhang, Xiuru
AU - Kashiwazaki, Haruhiko
AU - Yamazaki, Yutaka
AU - Inoue, Nobuo
AU - Moriuchi, Tetsuya
PY - 2006
Y1 - 2006
N2 - Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.
AB - Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.
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U2 - 10.3727/000000006783981080
DO - 10.3727/000000006783981080
M3 - Article
C2 - 17294802
AN - SCOPUS:33846837227
SN - 0965-0407
VL - 16
SP - 217
EP - 224
JO - Oncology Research
JF - Oncology Research
IS - 5
ER -
