Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues

Nur Mohammad Monsur Hassan, Jun Ichi Hamada, Taichi Murai, Akihusa Seino, Yoko Takahashi, Mitsuhiro Tada, Xiuru Zhang, Haruhiko Kashiwazaki, Yutaka Yamazaki, Nobuo Inoue, Tetsuya Moriuchi

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalOncology Research
Issue number5
Publication statusPublished - 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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