A tris(2,2′-bipyridine)ruthenium(ii) derivative tethered to a cis-PtCl2(amine)2 moiety: Syntheses, spectroscopic properties, and visible-light-induced scission of DNA

Ken Sakai; Hironobu Ozawa; Hajime Yamada; Taro Tsubomura; Mariko Hara; Akon Higuchi; Masa Aki Haga

doi:10.1039/b600165c

A tris(2,2′-bipyridine)ruthenium(ii) derivative tethered to a cis-PtCl₂(amine)₂ moiety: Syntheses, spectroscopic properties, and visible-light-induced scission of DNA

Ken Sakai, Hironobu Ozawa, Hajime Yamada, Taro Tsubomura, Mariko Hara, Akon Higuchi, Masa Aki Haga

Inorganic and Analytical Chemistry

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Abstract

A tris(2,2′-bipyridine)ruthenium(ii) derivative having two N-(3-ammoniopropyl)carbamoyl pendant units has been prepared and reacted with cis-PtCl₂(DMSO)₂ (DMSO = dimethyl sulfoxide) to give a heteronuclear Ru(ii)Pt(ii) dimer having a cis-Pt(ii)Cl₂(aliphatic amine)₂ unit, [Ru(bpy)₂(-bridge)PtCl₂](PF ₆)₂ (bpy = 2,2′-bipyridine, bridge = 4,4′-bis(N-(3-aminopropyl)carbamoyl)-2,2′-bipyridine). The ESI-TOF mass spectrum of the Ru(ii)Pt(ii) dimer shows a set of signals corresponding to {[Ru(bpy)₂(-bridge)PtCl₂](PF₆)}⁺ (m/z 1181.1). The MLCT (metal-to-ligand charge transfer) luminescence intensity is enhanced upon the platination of two amine units, presumably due to the formation of a relatively rigid metallocycle. More interestingly, the luminescence intensity is further enhanced by the complexation of the Ru(ii)Pt(ii) dimer with either 5′-GMP (guanosine 5′-monophosphate disodium salt) or calf thymus DNA. Visible-light-induced scission of supercoiled pBR322 DNA is found to be efficiently enhanced in the presence of the title Ru(ii)Pt(ii) dimer.

Original language	English
Pages (from-to)	3300-3305
Number of pages	6
Journal	Dalton Transactions
Issue number	27
DOIs	https://doi.org/10.1039/b600165c
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Inorganic Chemistry

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10.1039/b600165c

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@article{68a46784bd33422eae01e602e4fd53a8,

title = "A tris(2,2′-bipyridine)ruthenium(ii) derivative tethered to a cis-PtCl2(amine)2 moiety: Syntheses, spectroscopic properties, and visible-light-induced scission of DNA",

abstract = "A tris(2,2′-bipyridine)ruthenium(ii) derivative having two N-(3-ammoniopropyl)carbamoyl pendant units has been prepared and reacted with cis-PtCl2(DMSO)2 (DMSO = dimethyl sulfoxide) to give a heteronuclear Ru(ii)Pt(ii) dimer having a cis-Pt(ii)Cl2(aliphatic amine)2 unit, [Ru(bpy)2(-bridge)PtCl2](PF 6)2 (bpy = 2,2′-bipyridine, bridge = 4,4′-bis(N-(3-aminopropyl)carbamoyl)-2,2′-bipyridine). The ESI-TOF mass spectrum of the Ru(ii)Pt(ii) dimer shows a set of signals corresponding to {[Ru(bpy)2(-bridge)PtCl2](PF6)}+ (m/z 1181.1). The MLCT (metal-to-ligand charge transfer) luminescence intensity is enhanced upon the platination of two amine units, presumably due to the formation of a relatively rigid metallocycle. More interestingly, the luminescence intensity is further enhanced by the complexation of the Ru(ii)Pt(ii) dimer with either 5′-GMP (guanosine 5′-monophosphate disodium salt) or calf thymus DNA. Visible-light-induced scission of supercoiled pBR322 DNA is found to be efficiently enhanced in the presence of the title Ru(ii)Pt(ii) dimer.",

author = "Ken Sakai and Hironobu Ozawa and Hajime Yamada and Taro Tsubomura and Mariko Hara and Akon Higuchi and Haga, {Masa Aki}",

year = "2006",

doi = "10.1039/b600165c",

language = "English",

pages = "3300--3305",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "27",

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T1 - A tris(2,2′-bipyridine)ruthenium(ii) derivative tethered to a cis-PtCl2(amine)2 moiety

T2 - Syntheses, spectroscopic properties, and visible-light-induced scission of DNA

AU - Sakai, Ken

AU - Ozawa, Hironobu

AU - Yamada, Hajime

AU - Tsubomura, Taro

AU - Hara, Mariko

AU - Higuchi, Akon

AU - Haga, Masa Aki

PY - 2006

Y1 - 2006

N2 - A tris(2,2′-bipyridine)ruthenium(ii) derivative having two N-(3-ammoniopropyl)carbamoyl pendant units has been prepared and reacted with cis-PtCl2(DMSO)2 (DMSO = dimethyl sulfoxide) to give a heteronuclear Ru(ii)Pt(ii) dimer having a cis-Pt(ii)Cl2(aliphatic amine)2 unit, [Ru(bpy)2(-bridge)PtCl2](PF 6)2 (bpy = 2,2′-bipyridine, bridge = 4,4′-bis(N-(3-aminopropyl)carbamoyl)-2,2′-bipyridine). The ESI-TOF mass spectrum of the Ru(ii)Pt(ii) dimer shows a set of signals corresponding to {[Ru(bpy)2(-bridge)PtCl2](PF6)}+ (m/z 1181.1). The MLCT (metal-to-ligand charge transfer) luminescence intensity is enhanced upon the platination of two amine units, presumably due to the formation of a relatively rigid metallocycle. More interestingly, the luminescence intensity is further enhanced by the complexation of the Ru(ii)Pt(ii) dimer with either 5′-GMP (guanosine 5′-monophosphate disodium salt) or calf thymus DNA. Visible-light-induced scission of supercoiled pBR322 DNA is found to be efficiently enhanced in the presence of the title Ru(ii)Pt(ii) dimer.

AB - A tris(2,2′-bipyridine)ruthenium(ii) derivative having two N-(3-ammoniopropyl)carbamoyl pendant units has been prepared and reacted with cis-PtCl2(DMSO)2 (DMSO = dimethyl sulfoxide) to give a heteronuclear Ru(ii)Pt(ii) dimer having a cis-Pt(ii)Cl2(aliphatic amine)2 unit, [Ru(bpy)2(-bridge)PtCl2](PF 6)2 (bpy = 2,2′-bipyridine, bridge = 4,4′-bis(N-(3-aminopropyl)carbamoyl)-2,2′-bipyridine). The ESI-TOF mass spectrum of the Ru(ii)Pt(ii) dimer shows a set of signals corresponding to {[Ru(bpy)2(-bridge)PtCl2](PF6)}+ (m/z 1181.1). The MLCT (metal-to-ligand charge transfer) luminescence intensity is enhanced upon the platination of two amine units, presumably due to the formation of a relatively rigid metallocycle. More interestingly, the luminescence intensity is further enhanced by the complexation of the Ru(ii)Pt(ii) dimer with either 5′-GMP (guanosine 5′-monophosphate disodium salt) or calf thymus DNA. Visible-light-induced scission of supercoiled pBR322 DNA is found to be efficiently enhanced in the presence of the title Ru(ii)Pt(ii) dimer.

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U2 - 10.1039/b600165c

DO - 10.1039/b600165c

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AN - SCOPUS:33745727465

SN - 1477-9226

SP - 3300

EP - 3305

JO - Dalton Transactions

JF - Dalton Transactions

IS - 27

ER -

A tris(2,2′-bipyridine)ruthenium(ii) derivative tethered to a cis-PtCl₂(amine)₂ moiety: Syntheses, spectroscopic properties, and visible-light-induced scission of DNA

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