A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction

Isao Shimokawa; Masanori Utsuyama; Toshimitsu Komatsu; Haruyoshi Yamaza; Takuya Chiba

doi:10.1007/978-1-4020-9063-9_7

A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction

Isao Shimokawa, Masanori Utsuyama, Toshimitsu Komatsu, Haruyoshi Yamaza, Takuya Chiba

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Immunosenescence or dysregulation of the immune system may accelerate the aging process and shorten the lifespan in animals. Calorie restriction, a well-known nutritional intervention for longevity in laboratory animals, retards immunosenescence and modulates the immunosystem. These effects of CR could contribute partly to extending the lifespan. A transgenic (Tg) dwarf rat strain, in which the growth hormone (GH) axis is selectively suppressed, lived longer and exhibited several phenotypes similar to those in CR rats, suggesting an important role for the GH axis in the effect of CR. Here, we describe the longevity, pathology, thymic and splenic lymphocyte subpopulations and response to endotoxin in Tg rats in comparison with CR rats. The findings support the importance of the GH axis in the effect of CR on the immune system and, in particular, longevity. The Tg rats could be a useful tool to better understand the molecular mechanisms underlying the antiaging effect of CR.

Original language	English
Title of host publication	Handbook on Immunosenescence
Subtitle of host publication	Basic Understanding and Clinical Applications
Publisher	Springer Netherlands
Pages	131-144
Number of pages	14
Volume	9781402090639
ISBN (Electronic)	9781402090639
ISBN (Print)	9781402090622
DOIs	https://doi.org/10.1007/978-1-4020-9063-9_7
Publication status	Published - 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

Access to Document

10.1007/978-1-4020-9063-9_7

Cite this

Shimokawa, I., Utsuyama, M., Komatsu, T., Yamaza, H., & Chiba, T. (2009). A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (Vol. 9781402090639, pp. 131-144). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9_7

A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. / Shimokawa, Isao; Utsuyama, Masanori; Komatsu, Toshimitsu et al.
Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Vol. 9781402090639 Springer Netherlands, 2009. p. 131-144.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Shimokawa, I, Utsuyama, M, Komatsu, T, Yamaza, H & Chiba, T 2009, A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. in Handbook on Immunosenescence: Basic Understanding and Clinical Applications. vol. 9781402090639, Springer Netherlands, pp. 131-144. https://doi.org/10.1007/978-1-4020-9063-9_7

@inbook{505cdd16a0754cd88777a0d7c69ffa40,

title = "A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction",

abstract = "Immunosenescence or dysregulation of the immune system may accelerate the aging process and shorten the lifespan in animals. Calorie restriction, a well-known nutritional intervention for longevity in laboratory animals, retards immunosenescence and modulates the immunosystem. These effects of CR could contribute partly to extending the lifespan. A transgenic (Tg) dwarf rat strain, in which the growth hormone (GH) axis is selectively suppressed, lived longer and exhibited several phenotypes similar to those in CR rats, suggesting an important role for the GH axis in the effect of CR. Here, we describe the longevity, pathology, thymic and splenic lymphocyte subpopulations and response to endotoxin in Tg rats in comparison with CR rats. The findings support the importance of the GH axis in the effect of CR on the immune system and, in particular, longevity. The Tg rats could be a useful tool to better understand the molecular mechanisms underlying the antiaging effect of CR.",

author = "Isao Shimokawa and Masanori Utsuyama and Toshimitsu Komatsu and Haruyoshi Yamaza and Takuya Chiba",

year = "2009",

doi = "10.1007/978-1-4020-9063-9_7",

language = "English",

isbn = "9781402090622",

volume = "9781402090639",

pages = "131--144",

booktitle = "Handbook on Immunosenescence",

publisher = "Springer Netherlands",

address = "Netherlands",

}

TY - CHAP

T1 - A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction

AU - Shimokawa, Isao

AU - Utsuyama, Masanori

AU - Komatsu, Toshimitsu

AU - Yamaza, Haruyoshi

AU - Chiba, Takuya

PY - 2009

Y1 - 2009

N2 - Immunosenescence or dysregulation of the immune system may accelerate the aging process and shorten the lifespan in animals. Calorie restriction, a well-known nutritional intervention for longevity in laboratory animals, retards immunosenescence and modulates the immunosystem. These effects of CR could contribute partly to extending the lifespan. A transgenic (Tg) dwarf rat strain, in which the growth hormone (GH) axis is selectively suppressed, lived longer and exhibited several phenotypes similar to those in CR rats, suggesting an important role for the GH axis in the effect of CR. Here, we describe the longevity, pathology, thymic and splenic lymphocyte subpopulations and response to endotoxin in Tg rats in comparison with CR rats. The findings support the importance of the GH axis in the effect of CR on the immune system and, in particular, longevity. The Tg rats could be a useful tool to better understand the molecular mechanisms underlying the antiaging effect of CR.

AB - Immunosenescence or dysregulation of the immune system may accelerate the aging process and shorten the lifespan in animals. Calorie restriction, a well-known nutritional intervention for longevity in laboratory animals, retards immunosenescence and modulates the immunosystem. These effects of CR could contribute partly to extending the lifespan. A transgenic (Tg) dwarf rat strain, in which the growth hormone (GH) axis is selectively suppressed, lived longer and exhibited several phenotypes similar to those in CR rats, suggesting an important role for the GH axis in the effect of CR. Here, we describe the longevity, pathology, thymic and splenic lymphocyte subpopulations and response to endotoxin in Tg rats in comparison with CR rats. The findings support the importance of the GH axis in the effect of CR on the immune system and, in particular, longevity. The Tg rats could be a useful tool to better understand the molecular mechanisms underlying the antiaging effect of CR.

UR - http://www.scopus.com/inward/record.url?scp=84917740868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84917740868&partnerID=8YFLogxK

U2 - 10.1007/978-1-4020-9063-9_7

DO - 10.1007/978-1-4020-9063-9_7

M3 - Chapter

AN - SCOPUS:84917740868

SN - 9781402090622

VL - 9781402090639

SP - 131

EP - 144

BT - Handbook on Immunosenescence

PB - Springer Netherlands

ER -

A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this