A suppressor T cell in the human mixed lymphocyte reaction*

A. J. McMichael, T. Sasazuki

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)


Lymphocytes from an HLA-B7 DW2 homozygous multiparous woman, J.H., failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband, W.H., and certain other homozygous typing cells. J.H. lymphocytes could suppress the response of HLA matched responders to W.H. This effect was shown to be radiosensitive and due to a T cell. The suppressor cell showed antigen specificity.

Original languageEnglish
Pages (from-to)368-380
Number of pages13
JournalJournal of Experimental Medicine
Issue number2
Publication statusPublished - Aug 1 1977
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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