A study on the relationship between electrical transmural heterogeneity and ventricular energetics

Yuki Hasegawa, Mitsuharu Mishima, Takao Shimayoshi, Akira Amano, Tetsuya Matsuda

Research output: Contribution to journalArticlepeer-review


In this study, we use cardiovascular simulation to gain new insights on the correlation between electrical heterogeneity and ventricular energetics. Although there are numerous in vivo and in vitro studies on the electrical heterogeneity within the ventricular myocardium, not much attention has been directed to its correlation to cardiovascular mechanics, because of difficulties in simultaneously observing and analyzing multiple spatial scales (the cell, the organ, and the system). We performed simulations with two cardiovascular simulation models, one which uses different myocardial cell models for the epicardial, endocardial, and mid-myocardial cells, and another which uses a homogeneous model throughout the entire myocardium. The epicardial, endocardial, and midmyocardial cell models were created by parametrically tuning a homogenous cell model. From the cardiovascular simulation we obtained pressure-volume loops which were used to calculate cardiovascular energetic efficiency and myocardial contractility. We found that energetic efficiency is higher in the electrically heterogeneous model.

Original languageEnglish
Pages (from-to)6854-6857
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Publication statusPublished - 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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