A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure

Masatoshi Maeki; Tatsuyoshi Saito; Yusuke Sato; Takao Yasui; Noritada Kaji; Akihiko Ishida; Hirofumi Tani; Yoshinobu Baba; Hideyoshi Harashima; Manabu Tokeshi

doi:10.1039/c5ra04690d

A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure

Masatoshi Maeki, Tatsuyoshi Saito, Yusuke Sato, Takao Yasui, Noritada Kaji, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Hideyoshi Harashima, Manabu Tokeshi

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Formation behavior of lipid nanoparticles (LNPs) in microfluidic devices with a staggered herringbone micromixer (SHM) structure was investigated. The fundamental role for SHMs in LNP formation was demonstrated by determining such factors as the limiting SHM cycle numbers and the effect of flow rate. The SHM cycle numbers and the position of the first SHM were as significant as factors as the flow rate condition for producing the small-size LNPs.

Original language	English
Pages (from-to)	46181-46185
Number of pages	5
Journal	RSC Advances
Volume	5
Issue number	57
DOIs	https://doi.org/10.1039/c5ra04690d
Publication status	Published - 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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abstract = "Formation behavior of lipid nanoparticles (LNPs) in microfluidic devices with a staggered herringbone micromixer (SHM) structure was investigated. The fundamental role for SHMs in LNP formation was demonstrated by determining such factors as the limiting SHM cycle numbers and the effect of flow rate. The SHM cycle numbers and the position of the first SHM were as significant as factors as the flow rate condition for producing the small-size LNPs.",

author = "Masatoshi Maeki and Tatsuyoshi Saito and Yusuke Sato and Takao Yasui and Noritada Kaji and Akihiko Ishida and Hirofumi Tani and Yoshinobu Baba and Hideyoshi Harashima and Manabu Tokeshi",

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T1 - A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure

AU - Maeki, Masatoshi

AU - Saito, Tatsuyoshi

AU - Sato, Yusuke

AU - Yasui, Takao

AU - Kaji, Noritada

AU - Ishida, Akihiko

AU - Tani, Hirofumi

AU - Baba, Yoshinobu

AU - Harashima, Hideyoshi

AU - Tokeshi, Manabu

PY - 2015

Y1 - 2015

N2 - Formation behavior of lipid nanoparticles (LNPs) in microfluidic devices with a staggered herringbone micromixer (SHM) structure was investigated. The fundamental role for SHMs in LNP formation was demonstrated by determining such factors as the limiting SHM cycle numbers and the effect of flow rate. The SHM cycle numbers and the position of the first SHM were as significant as factors as the flow rate condition for producing the small-size LNPs.

AB - Formation behavior of lipid nanoparticles (LNPs) in microfluidic devices with a staggered herringbone micromixer (SHM) structure was investigated. The fundamental role for SHMs in LNP formation was demonstrated by determining such factors as the limiting SHM cycle numbers and the effect of flow rate. The SHM cycle numbers and the position of the first SHM were as significant as factors as the flow rate condition for producing the small-size LNPs.

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EP - 46185

JO - RSC Advances

JF - RSC Advances

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ER -

A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure

Abstract

All Science Journal Classification (ASJC) codes

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